« Previous
Next »
Archives of Medical Research
Volume 37, Issue 6
, Pages 700-708
, August 2006
Trimetazidine-Induced Enhancement of Myocardial Recovery during Reperfusion: A Comparative Study in Diabetic and Non-diabetic Rat Hearts
References
- . Diabetes mellitus and cardiovascular disease. Eur J Med. 2002;13:15–30
- Diabetes and cardiovascular disease. A statement for healthcare professionals from the American Heart Association. Circulation. 1999;100:1134–1146
- . What cardiologist needs to know about diabetes?. Lancet. 1997;350(Suppl 1):123–127
- . Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial. Diabetes Care. 1993;16:434–444
- Angiographic findings and outcome in diabetic patients treated with thrombolytic therapy for acute myocardial infarction. The GUSTO-I experience. J Am Coll Cardiol. 1996;28:1661–1669
- . Coronary artery disease and coronary artery bypass grafting in diabetic patients aged > or = 65 years (report from the coronary Artery Surgery Study [CASS] Registry). Am J Cardiol. 1994;74:334–339
- . Regulation by insulin of myocardial glucose and fatty acid metabolism in the conscious dog. J Clin Invest. 1948;74:1073–1079
- . Metabolic considerations in the treatment of coronary disease in diabetic patients. Diabetes Metab. 2001;27(5Pt 2):25–29
- . Treating dyslipidaemia in non-insulin dependent diabetes mellitus—a special reference to statins. J Diabetes Complic. 2001;15:211–226
- . Management of ischemic heart disease in diabetic patients—is there a role for cardiac metabolic agents. Curr Med Res Opin. 2001;17:1–6
- . New anti-ischaemic drugs. Cytoprotective action with no primary hemodynamic effects. Trends Pharmacol Sci. 1989;10:379–400
- . Rationale for trimetazidine administration in myocardial ischemia-reperfusion syndrome. Eur Heart J. 1993;14:34–40
- . The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000;86:580–588
- . Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease: a double-blind placebo-controlled study. Cardiovasc Diabetol. 2003;2:16
- . The effect of insulin-dependent diabetes mellitus on basal and distention-induced acid and pepsin secretion in rat. Diabetes Res Clin Pr. 2004;16:1–6
- Trimetazidine protects isolated rat hearts against ischemia-reperfusion injury in an experimental timing-dependent manner. Basic Res Cardiol. 2005;100:154–160
- Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am Heart J. 2003;146(5):E18
- . Energy metabolism of the heart: from basic concepts to clinical applications. Curr Prob Cardiol. 1994;19:59–113
- . Effects of heart work and insulin on glycogen metabolism in the perfused rat heart. Am J Physiol. 1973;224:7–12
- . Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventions. Cardiovasc Res. 1997;33:243–257
- . Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated?. Coron Artery Dis. 2001;12:8–11
- . Regulation of energy substrate metabolism in the diabetic heart. Cardiovasc Res. 1997;34:25–33
- . The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;ii:785–789
- . An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemia hearts. J Pharmacol Exp Ther. 1993;264:135–144
- . Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting and refeeding on pyruvate dehydrogenase interconversion. Arch Biochem Biophys. 1971;143:593–601
- . Anti-ischemic effects of trimetazidine: 31P-NMR spectroscopy in the isolated rat heart. Arch Int Pharmacodyn Ther. 1987;286:97–110
- . Internal pH, Na+ and Ca2+ regulation by trimetazidine during cardiac cell acidosis. Cardiovasc Drugs Ther. 1988;1:677–686
- . Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells. Br J Clin Pharmacol. 1985;20:148–151
- . Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation. J Mol Cell Cardiol. 1994;26:949–958
- . Effects of trimetazidine on ischemic contracture in isolated rat hearts. J Cardiovasc Pharmacol. 1994;24:45–49
- . Which left ventricular function is impaired earlier in the evaluation of diabetic cardiomyopathy? An echocardiographic study of young type I diabetic patients. Diabetes Care. 1994;17:633–639
- . Prevalance of diastolic dysfunction in normotensive asymptomatic patients with well-controlled type 2 diabetes mellitus. Am J Cardiol. 2001;87:320–323
- . Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res. 1988;62:535–542
- . Effects of trimetazidine on pHi regulation in the rat isolated ventricular myocyte. Br J Pharmacol. 1996;117:831–838
- . The role of oxidative stress in diabetic vascular and neural disease. Free Radic Res. 2003;37:471–480
- Ischemia-reperfusion injury during experimental heart transplantation. Evaluation of trimetazidine's cytoprotective effect. Rev Esp Cardiol. 2005;58(8):941–950
PII: S0188-4409(06)00088-9
doi: 10.1016/j.arcmed.2006.01.008
© 2006 IMSS. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Archives of Medical Research
Volume 37, Issue 6
, Pages 700-708
, August 2006
