Archives of Medical Research
Volume 37, Issue 6 , Pages 723-729 , August 2006

In Vitro Antiproliferative Effects of Neuroleptics, Antimycotics and Antibiotics on the Human Pathogens Acanthamoeba polyphaga and Naegleria fowleri

  • Raúl N. Ondarza

      Affiliations

    • Center for Research on Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    • Department of Biochemistry, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
    • Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California–San Diego (UCSD), La Jolla, California
    • Corresponding Author InformationAddress reprint requests to: Raúl N. Ondarza, Olivar de los Padres 941, 0178 México, D.F., México.
    • ,
  • Angelica Iturbe

      Affiliations

    • Center for Research on Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico
    • ,
  • Eva Hernández

      Affiliations

    • Center for Research on Infectious Diseases, National Institute of Public Health, Cuernavaca, Morelos, Mexico

Received 25 November 2005 ,Accepted 2 February 2006.

References 

  1. Ficker L, Seal D, Warhurst D, Wright P. Acanthamoeba keratitis—resistance to medical therapy. Eye. 1990;4(Pt6):835–838
  2. Hargrave SL, McCulley JP, Husseini Z. Results of a trial of combined propamidine isethionate and neomycin therapy for Acanthamoeba keratitis. Brolene Study Group. Ophthalmology. 1999;106:952–957
  3. Seal DV, Hay J, Kirkness CM. Chlorhexidine or polyhexamethylene biguanide for Acanthamoeba keratitis. Lancet. 1995;345(8942):136
  4. John DT. Opportunistically pathogenic free-living amebae. In:  Kreier JP,  Baker JR editor. Parasitic Protozoa. 2nd ed.. San Diego: Academic Press; 1993;p. 143–246
  5. Fahey RC, Newton GL, Arrick B, Overdank-Bogart T, Aley SB. Entamoeba histolytica: a eukaryote without glutathione metabolism. Science. 1984;224:70–72
  6. Ondarza RN, Hernandez E, Iturbe A, Hurtado G. Inhibitory and lytic effects of phenothiazine derivatives and related tricyclic neuroleptic compounds, on Entamoeba histolytica HK9 and HM1 trophozoites. Biotechnol Appl Biochem. 2000;32(Pt 1):61–67
  7. Ondarza RN, Iturbe A, Hernandez E, Tamayo EM, Hurtado G. In vivo inhibition of reduced thiol compounds from Entamoeba histolytica HK9 by phenothiazines and related tricyclic drugs. Arch Med Res. 2000;31(4):S12–S16
  8. National Committee for Clinical Laboratory Standards: Performance standards for antimicrobial susceptibility testing. Twelfth Informational Supplement. Wayne PA: NCCLS, 2002;22(1). Document M100–S12.
  9. Schuster FL, Mandel N. Phenothiazine compounds inhibit in vitro growth of pathogenic free-living amoebae. Antimicrob Agents Chemother. 1984;25(1):109–112
  10. Goswick SM, Brenner GM. Activities of azithromycin and amphotericin B against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. Antimicrob Agents Chemother. 2003;47(2):524–528
  11. Goswick SM, Brenner GM. Activities of therapeutic agents against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. J. Parasitol. 2003;89(4):837–842
  12. Schuster FL, Visvesvara GS. Amebic encephalitides and amebic keratitis caused by pathogenic and opportunistic free-living amebas. Curr Treat Options Infect Dis. 2003;5:273–282
  13. Mattana A, Biancu MG, Alberti L, Accardo A, Delogu G, Fiori PL, et al. In vitro evaluation of the effectiveness of the macrolide rokitamycin and chlorpromazine against Acanthamoeba castellanii. Antimicrob Agents Chemother. 2004;48:4520–4527
  14. Duma JR, Finley R. In vitro susceptibility of pathogenic Naegleria and Acanthamoeba to a variety of therapeutic agents. Antimicrob Agents Chemother. 1976;10:370–376
  15. Vargas-Zepeda J, Gomez-Alcala AV, Vasquez-Morales JA, Licea-Amaya L, De Jonckheere JF, Lares-Villa F. Successful treatment of Naegleria fowleri meningoencephalitis by using intravenous amphotericin B, fluconazole and rifampicin. Arch Med Res. 2005;36(1):83–86

PII: S0188-4409(06)00096-8

doi: 10.1016/j.arcmed.2006.02.007

Archives of Medical Research
Volume 37, Issue 6 , Pages 723-729 , August 2006

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