Archives of Medical Research
Volume 37, Issue 6 , Pages 755-759 , August 2006

Thrombocytosis in Pediatric Patients Is Associated with Severe Lower Respiratory Tract Inflammation

  • Vasiliki Vlacha

      Affiliations

    • Division of Pediatric Hematology−Oncology, Department of Pediatrics, University Hospital of Patras, Patras, Greece
    • Corresponding Author InformationAddress reprint requests to: Dr. Vasiliki Vlacha, Division of Pediatric Hematology−Oncology, Department of Pediatrics, University Hospital of Patras School of Medicine, General University Hospital, 26504 Rion, Patras, Greece
    • ,
  • Gavriela Feketea

      Affiliations

    • General Hospital of Amaliada, Amaliada, Greece

Received 21 July 2005 ,Accepted 2 February 2006.

References 

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  2. Yohannan MD, Higgy KE, al-Mashhadani SA, Santhosh-Kumar CR. Thrombocytosis. Etiologic analysis of 663 patients. Clin Pediatr. 1994;33(6):340–343
  3. Shimada H, Oohira G, Okazumi S, Matsubara H, Nabeya Y, Hayashi H, et al. Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma. Am J Coll Surg. 2004;198(5):737–741
  4. Garoufi A, Voutsioti K, Tsapra H, Karpathios T, Zeis PM. Reactive thrombocytosis in children with upper urinary tract infections. Acta Paediatr. 2001;90:448–449
  5. Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. J Interferon Cytokine Res. 2002;22(9):913–922
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  7. Ishiguro A, Suzuki Y, Mito M, Shombo T, Matsubara K, Kato T, et al. Elevation of serum thrombopoietin precedes thrombocytosis in acute infections. Br J Haematol. 2002;116(3):612–618
  8. Kaser A, Brandacher G, Steurer W, Kaser S, Offner FA, Zoller H, et al. Interleukin-6 stimulates thrombopoiesis through thrombopoietin and the role in inflammatory thrombocytosis. Blood. 2001;98(9):2720–2725
  9. Hsu HC, Tsai WH, Jiang ML, Ogata K, Yamada T, Ohki I, et al. Circulating levels of thrombopoietic and inflammatory cytokines in patients with clonal and reactive thrombocytosis. J Lab Clin Med. 1999;134(4):392–397
  10. Dan K, Gomi S, Inokuchi K, Ogata K, Yamada T, Ohki I, et al. Effects of interleukin-1 and tumor necrosis factor on megakaryocytopoiesis: mechanism of reactive thrombocytosis. Acta Haematol. 1995;93(2–4):67–72
  11. Fernandez-Serrano S, Dorca J, Coromines M, Carratala J, Gudiol F, Manresa F. Molecular inflammatory responses measured in blood of patients with severe community-acquired pneumonia. Clin Diagn Lab Immunol. 2003;10(5):813–820
  12. Greene C, Lowe G, Taggart C, Gallagher P, McElvaney N, O'Neill S. Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia. J Infect Dis. 2002;186(12):1790–1796
  13. Wolach B, Morag H, Drucker M, Sadan N. Thrombocytosis after pneumonia and empyema and other bacterial infections in children. Pediatr Infect Dis J. 1990;9(10):718–721
  14. Delclaux C, Azoulay E. Inflammatory response to infectious pulmonary injury. Eur Respir J. 2003;42(suppl):10s–14s
  15. Yokoyama A, Maruyama M, Ito M, Kohno N, Hiwada K, Yano S. Interleukin-6 activity in pleural effusion. Its diagnostic value and thrombopoietic activity. Chest. 1992;102(4):1055–1059

PII: S0188-4409(06)00098-1

doi: 10.1016/j.arcmed.2006.02.009

Archives of Medical Research
Volume 37, Issue 6 , Pages 755-759 , August 2006

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