Archives of Medical Research
Volume 37, Issue 7 , Pages 854-859 , October 2006

Leptin Receptor Lys656Asn Polymorphism Is Associated with Decreased Leptin Response and Weight Loss Secondary to a Lifestyle Modification in Obese Patients

Received 7 March 2006 ,Accepted 31 March 2006.

References 

  1. Friedman JM, Halas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763–770
  2. Lee GH, Proenca R, Montez JM. Abnormal splicing of leptin receptor in diabetic mice. Nature. 1996;379:632–635
  3. Clement K, Vaisse C, Lahlou N. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;329:398–401
  4. Considine RV, Sinha MK, Heiman ML. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292–295
  5. Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404:661–671
  6. Clement K. Leptin and the genetics of obesity. Acta Paediatr. 1999;88:51–57
  7. Heo M, Leíble RL, Boyer BB, Cheng WK, Koulu M, Karnoven MK, et al. Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity. Genetics. 2001;159:1163–1178
  8. Knowler WC, Barret-Connor E, Fowler SE. Diabetes Prevention Program Research Group. Reduction in incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393–403
  9. Mathews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF. Homeostasis model assessment: insulin resistance and beta cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–414
  10. Pichard C, Slosman D, Hirschel B, Kyle U. Bioimpedance analysis in AIDS patients: an improved method for nutritional follow up. Clin Res. 1993;41:53a
  11. Mataix J, Mañas M. Tablas de composición de alimentos españoles. Granada, Spain: Ed. University of Granada; 1998;
  12. Mars M, Van Rossum C, de Graaf C, Hoebee B, de Groot L, Kok FJ. Leptin responsiveness to energy restriction: genetic variation in the leptin receptor gene. Obes Res. 2004;12:442–446
  13. Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphism with body mass index and waist circumference. Int J Obes. 2002;26:640–646
  14. Gotoda T, Manning BS, Goldstone AP, Imrie H, Evans AL, Strosberg AD. Leptin receptor gene variation and obesity: lack of association in a white British male population. Human Mol Genet. 2004;6:869–876
  15. Wauters M, Mertens I, Rankinen T, Chagnon C, Bouchard C, Van Gaal L. Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance. J Clin Endocrinol Metab. 2001;86:3227–3232
  16. Wauters M, Considine R, Chagnon M, Mertens I, Rankinen T, Bouchard C, et al. Leptin levels, leptin receptor gene polymorphisms, and energy metabolism in women. Obes Res. 2002;10:394–400
  17. Lakka T, Rankinen T, Weisnagel SJ, Chagnon YC, Lakka HM, Ukkola O, et al. Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals. Diabetes. 2004;53:1603–1610
  18. Rossum CTM, Hoebee B, van Baak M, Mars M, Saris WHM, Seidell JC. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes Res. 2003;11:377–386
  19. Mammes O, Aubert R, Betoulle D, Pean F, Herbetch B, Visvikis S, et al. LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women. Eur J Clin Invest. 2001;31:398–404
  20. Mars M, Van Rossum CT, de Graaf C, Hoebee B, De Groot LC, Kok FJ. Leptin responsiveness to energy restriction: genetic variation in the leptin receptor genes. Obes Res. 2004;12:442–444
  21. Frayn KN, Karpe F, Fielding BA, Macdonald IA, Coppack SW. Integrative physiology of human adipose tissue. Int J Obes Relat Metab Disord. 2003;27:875–888
  22. Xenachis C, Samojlik E, Raghuwanshi MP, Kirschner MA. Leptin, insulin and TNF-alpha in weight loss. J Endocrinol Invest. 2001;24:865–870
  23. Bastard JP, Jardel C, Bruckert E. Elevated levels of interleukin-6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab. 2000;85:3338–3342
  24. Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mulloly C, Jarema C, et al. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res. 2003;11:1048–1052

PII: S0188-4409(06)00150-0

doi: 10.1016/j.arcmed.2006.03.009

Archives of Medical Research
Volume 37, Issue 7 , Pages 854-859 , October 2006

Article Tools