Archives of Medical Research
Volume 37, Issue 7 , Pages 860-865 , October 2006

5-Fluorouracil and Weekly Oxaliplatin Combined with Radiotherapy for Locally Advanced Rectal Cancer: Surgical Complications and Long-term Results

  • Salvatore Pucciarelli

      Affiliations

    • Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, Padova, Italy
    • Corresponding Author InformationAddress reprint requests to: Salvatore Pucciarelli, M.D., Dipartimento di Scienze Oncologiche e Chirurgiche, Sezione di Clinica Chirurgica II, Policlinico, VI piano, Via Giustiniani, 2, 35128 Padova Italy
    • ,
  • Emanuele Urso

      Affiliations

    • Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, Padova, Italy
    • ,
  • Gian Luca DeSalvo

      Affiliations

    • Servizio Sperimentazioni Cliniche e Biostatistica, Istituto Oncologico Veneto, Padova, Italy
    • ,
  • Carlo Aschele

      Affiliations

    • Oncologia Medica, Ospedale Galliera di Genova, Genova, Italy
    • ,
  • Maria Luisa Friso

      Affiliations

    • Divisione di Radioterapia, Azienda Ospedaliera, Padova, Italy
    • ,
  • Massimo Rugge

      Affiliations

    • Istituto di Anatomia Patologica, Padova, Italy
    • ,
  • Paola Toppan

      Affiliations

    • Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, Padova, Italy
    • ,
  • Andrea Bruttocao

      Affiliations

    • Chirurgia Geriatrica, Padova, Italy
    • ,
  • Giuliano Fabris

      Affiliations

    • Chirurgia Generale, Azienda Ospedaliera, Padova, Italy
    • ,
  • Benito Ferraro

      Affiliations

    • U.O. di Chirurgia, Ospedale San Antonio, Padova, Italy
    • ,
  • Sara Lonardi

      Affiliations

    • Divisione di Oncologia Medica, Azienda Ospedaliera, Padova, Italy
    • ,
  • Mauro Frego

      Affiliations

    • Clinica Chirurgica I, Padova, Italy
    • ,
  • Cristiano Finco

      Affiliations

    • Clinica Chirurgica III University of Padova, Padova, Italy
    • ,
  • Mario Lise

      Affiliations

    • Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, Padova, Italy
    • ,
  • Donato Nitti

      Affiliations

    • Clinica Chirurgica II, Dipartimento di Scienze Oncologiche e Chirurgiche, Padova, Italy

Received 11 August 2005 ,Accepted 3 April 2006.

References 

  1. Heald RJ, Husband EM, Ryall RDH. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet. 1986;1:1479–1482
  2. Kapiteijn E, Marijnen CA, Nagtegaal ID, Putter H, Steup WH, Wiggers T, et al. and the Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638–646
  3. Gastrointestinal Tumour Study Group . Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med. 1985;312:1465–1472
  4. Krook JE, Moertel CG, Gunderson LL, Wieand HS, Collins RT, Beart RW, et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med. 1991;324:709–715
  5. NIH Consensus Conference . Adjuvant therapy for patients with colon and rectal cancer. JAMA. 1990;264:1444–1450
  6. Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R, et al. and the German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731–1740
  7. Nelson H, Sargent DJ. Refining multimodal therapy for rectal cancer. N Engl J Med. 2001;345:690–692
  8. de Gramont A, Figer A, Seymour M, Homarin M, Hmissi A, Cassidy J, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol. 2000;18:2938–2947
  9. Giacchetti S, Perpoint B, Zidani R, Le Bail N, Fagginolo R, Focan C, et al. Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2000;18:136–147
  10. Blackstock AW, Hess S, Chaney S, Tepper JE. Oxaliplatin: in vitro evidence of its radiation sensitizing activity. Pre-clinical observations relevant to clinical trials. Int J Radiat Oncol Biol Phys. 1999;45(Suppl 1):253–254
  11. Freyer G, Bossard N, Romestaing P, Mornex F, Chapet O, Trillet-Lenoir V, et al. Addition of oxaliplatin to continuous fluorouracil l-folinic acid and concomitant radiotherapy in rectal cancer: the Lyon R97–03 phase I trial. J Clin Oncol. 2001;19:2433–2438
  12. Carraro S, Roca EL, Cartelli C, Rafailovici L, Castillo Odena S, Wasserman E, et al. Radiochemotherapy with short daily infusion of low-dose oxaliplatin, leucovorin, and 5-FU in T3–T4 unresectable rectal cancer: a phase II IATTGI study. Int J Radiat Oncol Biol Phys. 2002;54:397–402
  13. Gérard JP, Chapet O, Nemoz C, Romestaing P, Mornex F, Coquard R, et al. Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin-containing regimen: the Lyon R0–04 Phase II Trial. J Clin Oncol. 2003;21:1119–1124
  14. Aschele C, Friso ML, Pucciarelli S, Lonardi S, Sartor L, Fabris G, et al. A phase I–II study of weekly oxaliplatin, 5-fluorouracil continuous infusion and preoperative radiotherapy in locally advanced rectal cancer. Ann Oncol. 2005;16:1140–1166
  15. Chiesura-Corona M, Muzzio PC, Giust G, Zuliani M, Pucciarelli S, Toppan P. Rectal cancer: CT local staging with histopathological correlation. Abdom Imaging. 2001;26:134–138
  16. Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, et al. Common toxicity criteria: Version 2.0—An improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47:13–47
  17. Enker EW, Thaler TH, Cranon LM, Polyak T. Total mesorectal excision in the operative treatment of carcinoma of the rectum. J Am Coll Surg. 1995;181:335–346
  18. Quirke P, Durdey P, Dixon MF, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet. 1986;2:996–999
  19. AJCC American Joint Committee on Cancer. In:  Fleming DI,  Cooper SJ,  Henson ED,  Hutter VR,  Kennedy JB,  Murphy PG, et al. editor. AJCC Cancer Staging Manual. 5th ed.. Philadelphia: Lippincott-Raven; 1997;p. 83–90
  20. Compton CC, Fielding LP, Burgart LJ, Conley B, Cooper HS, Hamilton SR, et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus statement 1999. Arch Pathol Lab Med. 2000;124:979–994
  21. Enker WE, Merchant N, Cohen AM, Lanouette NM, Swallow C, Guillem J, et al. Safety and efficacy of low anterior resection for rectal cancer: 681 consecutive cases from a specialty service. Ann Surg. 1999;230:544–552
  22. Zaheer S, Pemberton JH, Farouk R, Dozois RR, Wolff BG, Ilstrup D. Surgical treatment of adenocarcinoma of the rectum. Ann Surg. 1998;227:800–811
  23. Marijnen CAM, Kapiteijn E, van de Velde CJH, Martijn H, Steup WH, Wiggers T, et al. Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol. 2002;20:817–825
  24. Karanjia ND, Corder AP, Bearn P, Heald RJ. Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg. 1994;81:1224–1226
  25. Vignali A, Fazio VW, Lavery IC, Milsom JW, Church JM, Hull TL, et al. Factors associated with the occurrence of leaks in stapled rectal anastomoses: a review of 1,014 patients. J Am Coll Surg. 1997;185:105–113
  26. Rodel C, Grabenbauer GG, Papadopoulos T, Hohenberger W, Schmoll HJ, Sauer R. Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer. J Clin Oncol. 2003;21:3098–3104
  27. Pucciarelli S, Toppan P, Friso ML, Russo V, Pasetto L, Urso E, et al. Complete pathologic response following preoperative chemoradiation therapy for middle to lower rectal cancer is not a prognostic factor for a better outcome. Dis Colon Rectum. 2004;47:1798–1807

PII: S0188-4409(06)00164-0

doi: 10.1016/j.arcmed.2006.04.008

Archives of Medical Research
Volume 37, Issue 7 , Pages 860-865 , October 2006

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