Archives of Medical Research
Volume 39, Issue 5 , Pages 489-495 , July 2008

Inhibition of Cardiomyocyte Contractile/Relaxation by MN9202 and Mechanisms Involved

  • Xiaoxing Zhu

      Affiliations

    • Department of Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China
    • Department of Pharmacology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
    • These authors contributed equally to this study.
  • ,
  • Xiaoling Zhu

      Affiliations

    • Department of Anesthesiology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
    • These authors contributed equally to this study.
  • ,
  • Xiaolin Niu

      Affiliations

    • Department of Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China
    • Corresponding Author InformationAddress reprint requests to: Xiaolin Niu, Department of Cardiology, Xi'an Jiatong University, No. 5 West Road, Xi'an, Shaanxi, 710032, PR China
  • ,
  • Jianming Pei

      Affiliations

    • Department of Physiology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
  • ,
  • Lize Xiong

      Affiliations

    • Department of Anesthesiology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
  • ,
  • Shaoyang Chen

      Affiliations

    • Department of Anesthesiology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
  • ,
  • Shun-Yan Lu

      Affiliations

    • Department of Physiology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
  • ,
  • Jin Wei

      Affiliations

    • Department of Cardiology, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China
  • ,
  • Bin Xing

      Affiliations

    • Department of Pharmacology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
  • ,
  • Li Liu

      Affiliations

    • Department of Pharmacology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
  • ,
  • Qibing Mei

      Affiliations

    • Department of Pharmacology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
  • ,
  • Miaozhang Zhu

      Affiliations

    • Department of Physiology, Fourth Military Medical University, Xi'an, Shaanxi, PR China
    • These authors contributed equally to this study.

Received 9 January 2008 ,Accepted 28 February 2008.

References 

  1. Mugellini A, Rinaldi A, Zoppi A, Lazzari P, Fogari E, Corradi L, et al. Effect of manidipine as compared to atenolol on platelet aggregation in elderly patients with isolated systolic hypertension and type II diabetes mellitus. J Cardiovasc Pharmacol. 2005;45:310–313
  2. Finkel MS, Romeo RC, Oddis CV, Salama G. Inotropic effects of calcium antagonists in the cardiomyopathic Syrian hamster. J Cardiovasc Pharmacol. 1992;19:546–553
  3. Messerli FH. Evolution of calcium antagonists: past, present, and future. J Clin Cardiol. 2003;26:1112–1116
  4. Wang LL, Mei QB, Zhao DH, Tian QL, Zhang ZL, et al. Effects of methylpenty1,4-dihydro-2,6-dimethyl-4-(3-nitro-phenyl)-3,5-pyridinediboxylate (MN9202) on experimental thrombosis. Chin Pharmacol J. 1998;33:282–285
  5. Gan G, Mei QB, Zhao DH. Protective effects of methylpenty1,4-dihydro-2,6-dimethyl-4-(3-nitro-phenyl)-3,5-pyridinediboxylate on shock induced by intestinal ischemia-reperfusion injury in rabbits. Chin J Pharmacol Toxicol. 1997;11:190–193
  6. Yang ZF, Zhou SY, Mei QB, Yang TH, Liu ZG. Metabolic kinetics of MN9202 in Beagle dog liver microsomes. Yao Xue Xue Bao. 2005;40:1019–1023
  7. Cui XL, Chen HZ, Wu DM, Wu DM. Enhancement of Ca2+ transients and contraction of single ventricular myocytes of rats by 5-(N,N-dimethyl) amiloride. Acta Physiol Sinica. 2002;54:219–224
  8. Yu J, Zhang HF, Wu F, Li QX, Ma H, Guo WY, et al. Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/reperfusion. Acta Pharmacol Sinica. 2006;27:919–926
  9. Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415:198–205
  10. Guo HT, Zhu MZ, Zhang RH, Bi H, Zhang B, Zhang HF, et al. Vasonatrin peptide attenuates the enhancement of electrically-induced [Ca2+]i transient by isoproterenol in rat cardiac myocytes. Acta Physiol Sinica. 2004;56:335–340
  11. Hintz KK, Norby FL, Duan JH, Cinnamon MA, Doze VA, Ren J. Comparison of cardiac excitation-contraction coupling in isolated ventricular myocytes between rat and mouse. Comp Biochem Physiol A: Mol Integ Physiol. 2002;133:191–198
  12. Okayama H, Hamada M, Kawakami H, Ikeda S, Hashida H, Shigematsu Y, et al. Increased contraction of myocytes isolated from the young spontaneously hypertensive rat: relationship between systolic and diastolic function. Am J Hypertens. 1998;11:349–356
  13. Shen JX, Wang SQ, Song LS, Han TZ, Cheng HP. Polymorphism of calcium sparks evoked from in-focus calcium release units in cardiac myocytes. Biophys J. 2004;86:182–190
  14. Berne RM, Levy MN. Cardiovascular Physiology. 8th ed.. Beijing: Health Science Asia, Elsevier Science; 2002;61–65
  15. Cheng H, Wang SQ. Calcium signaling between sarcolemmal calcium channels and ryanodine receptors in heart cells. Front Biosci. 2002;7:d1867–d1878
  16. Duan Y, Haugabook SJ, Sahley CL, Muller KJ. Methylene blue blocks cGMP production and disrupts directed migration of microglia to nerve lesions in the leech CNS. J Neurobiol. 2003;57:183–192
  17. Ziolo MT, Lewandowski SJ, Smith JM, Romano FD, Wahler GM. Inhibition of cyclic GMP hydrolysis with zaprinast reduces basal and cyclic AMP-elevated L-type calcium current in guinea-pig ventricular myocytes. Br J Pharmacol. 2003;138:986–994
  18. Shen JB, Pappano AJ. On the role of phosphatase in regulation of cardiac L-type calcium current by cyclic GMP. J Pharmacol Exp Therapeut. 2002;301:501–506
  19. Méry PF, Lohmann SM, Walter U, Fischmeister R. Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes. Proc Natl Acad Sci USA. 1991;88:1197–1201
  20. Sipido KR, Callewaert G, Carmeliet E. Inhibition and rapid recovery of Ca2+ current during Ca2+ release from sarcoplasmic reticulum in guinea pig ventricular myocytes. Circ Res. 1995;76:102–109
  21. Sumii K, Sperelakis N. cGMP-dependent protein kinase regulation of the L-type Ca2+ current in rat ventricular myocytes. Circ Res. 1995;77:803–812
  22. Grégoire V, Ignacio V, Catherine RM, Patrick DG, Rodolphe F. Cyclic GMP regulation of the L-type Ca2+ channel current in human atrial myocytes. J Physiol. 2001;533:329–340
  23. Snyders D. Structure and function of cardiac potassium channels. Cardiovasc Res. 1999;42:377–390

PII: S0188-4409(08)00090-8

doi: 10.1016/j.arcmed.2008.02.010

Archives of Medical Research
Volume 39, Issue 5 , Pages 489-495 , July 2008