Archives of Medical Research
Volume 40, Issue 4 , Pages 235-240 , May 2009

Knockdown of IGF-IR by RNAi Inhibits SW480 Colon Cancer Cells Growth In Vitro

  • Kamal Yavari

      Affiliations

    • Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    • ,
  • Mohammad Taghikhani

      Affiliations

    • Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    • Corresponding Author InformationAddress reprint requests to: Mohammad Taghikhani, Clinical Biochemistry, School of Medical Sciences, Tarbiat Modares University Tehran, Tehran, Iran, P.O. Box 14115-331
    • ,
  • Mohammad Ghannadi Maragheh

      Affiliations

    • Nuclear Sciences and Technology Research Institute, Tehran, Iran
    • ,
  • Seyed A. Mesbah-Namin

      Affiliations

    • Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    • ,
  • Mohammad Hosein Babaei

      Affiliations

    • Nuclear Sciences and Technology Research Institute, Tehran, Iran

Received 13 October 2008 ,Accepted 3 February 2009.

References 

  1. Cohen SJ, Cohen RB, Meropol NJ. Targeting signal transduction pathways in colorectal cancer—more than skin deep. J Clin Oncol. 2005;23:5374–5385
  2. Waters C. Colorectal cancer: an overview. Pharmaceut J. 2006;276:323–326
  3. Labianca R, Beretta G, Gatta G, de Braud F, Wils J. Colon cancer. Crit Rev Oncol Hematol. 2004;51:145–170
  4. Ansari R, Mahdavinia M, Sadjadi A, et al. Incidence and age distribution of colorectal cancer in Iran. Results of a population-based cancer registry. Cancer Lett. 2006;240:143–147
  5. Grady WM. Epigenetic events in the colorectum and in colon cancer. Biochem Soc Trans. 2005;33:684–686
  6. Williams NS, Gaynor RB, Scoggin S, et al. Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays. Clin Cancer Res. 2003;9:931–946
  7. Le Roith D, Roberts CT. The insulin-like growth factor system and cancer. Cancer Lett. 2003;195:127–137
  8. Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000;92:1472–1489
  9. Yakar S, Leroith D, Brodt P. The role of the growth hormone/insulin-like growth factor axis in tumor growth and progression: lessons from animal models. Cytokine Growth Factor Rev. 2005;16:407–420
  10. Baker J, Liu JP, Robertson EJ, Efstratiadis A. Role of insulin like growth factors in embryonic and postnatal growth. Cell. 1993;75:73–82
  11. Rosen CJ, Pollak M. Circulating IGF-I: new perspectives for a new century. Trends Endocrinol Metab. 1999;10:136–141
  12. Guerreiro AS, Boller D, Doepfner KT, Arcaro A. IGF-IR: potential role in antitumor agents. Drug News Perspect. 2006;19:261–272
  13. Sepp-Lorenzino L. Structure and function of the insulin-like growth factor I receptor. Breast Cancer Res Treat. 1998;47:235–253
  14. De Meyts P, Whittaker J. Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov. 2002;1:769–783
  15. Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev. 2007;28:20–47
  16. Valentinis B, Baserga R. IGF-I receptor signalling in transformation and differentiation. Clin Mol Pathol. 2001;54:133–137
  17. Favelyukis S, Till JH, Hubbard SR, Miller WT. Structure and autoregulation of the insulin like growth factor I receptors. Nat Struct Biol. 2001;8:1058–1063
  18. Roshanak M, Monzavi R. IGFs and IGFBPs: role in health and disease. Best Pract Res Clin Endocrinol Metab. 2002;16:437–447
  19. Stewart CE, Rotwein P. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol Rev. 1996;76:1005–1026
  20. Matthias MW, Christian F, Weber MM, Fottner C, Liu SB, et al. Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer. 2002;95:2086–2095
  21. Corinna B, Bernd G. The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res. 2004;14:287–295
  22. Burtrum D, Zhu Z, Lu D, et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res. 2003;63:8912–8921
  23. Sachdev D, Hartell JS, Lee AV. A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells. J Biol Chem. 2004;279:5017–5024
  24. Chernicky CL, Tan L, Gan SU, Ilan J. Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo. Cancer Gene Ther. 2000;7:384–395
  25. Gudkov AV, Zelnick CR, Kazarov AR, et al. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II—interactive cytotoxic drugs, from human topoisomerase II cDNA. Proc Natl Acad Sci USA. 1993;90:3231–3235
  26. Collins FS, Green ED, Guttmacher AE, Guyer MS. A vision for the future of genomic research. Nature. 2003;422:835–847
  27. Grünweller A, Wyszko E, Bieber B, Jahnel R, Erdmann VA, Kurreck J. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res. 2003;31:3185–3193
  28. Scherer LJ, Rossi JJ. Approaches for the sequence-specific knockdown of mRNA. Nat Biotechnol. 2003;21:1457–1465
  29. Milhavet O, Gary DS, Mattson MP. RNA interference in biology and medicine. Pharmacol Rev. 2003;55:629–648
  30. Pfeffer S, Meister G, Landthaler M, Tuschl T. RNA silencing. BIF FUTURA. 2005;20:83–90
  31. Downward J. RNA interference. Br Med J. 2004;328:1245–1248
  32. Sumimoto H. Use of RNA interference technology for specific gene silencing. Ann Cancer Res Ther. 2005;13:23–25
  33. Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol. 2003;4:457–467
  34. Barik S. Silence of the transcripts: RNA interference in medicine. J Mol Med. 2005;83:764–773
  35. Friedrich I, Shir A, Klein S, Levitzki A. RNA molecules as anti-cancer agents. Cancer Biol. 2004;14:223–230
  36. Massimo M, Giorgia N, Stefano I, Elena F, Masiero M, Nardo G, et al. RNA interference: implication for cancer treatment. Mol Aspect Med. 2007;28:143–166
  37. Chung G, Kerr DJ, Chung-Faya GA, Kerr DJ. Innovative treatment for colon cancer. Br Med J. 2000;321(321):1397–1399
  38. LeRoith D, Werner H, Beitner JD, Roberts CT. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev. 1995;16:143–163
  39. Uprichard SL. The therapeutic potential of RNA interference. FEBS Lett. 2005;579:5996–6007
  40. Bantounas I, Phylactou1 L, Uney JB. RNA interference and the use of small interfering RNA to study gene function in mammalian systems. J Mol Endocrinol. 2004;33:545–557
  41. Nagy P, Arndt-Jovin DJ, Jovin TM. Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor and induce apoptosis in erbB1-overexpressing cells. Exp Cell Res. 2003;285:39–49
  42. Sui G, Soohoo C, Affarel BB, et al. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA. 2002;99:5515–5520
  43. Vivek M, Mittal V. Improving the efficiency of RNA interference in mammals. Nature. 2004;5:355–365
  44. Tuschl T. Expanding small RNA interference. Nat Biotechnol. 2002;20:500–505
  45. Ajamete K, Randall TM, Kaykas A, Moon RT. A plasmid-based system for expressing small interfering RNA libraries in mammalian cells. BioMed Central Cell Biol. 2004;5:1–11
  46. Brummelkamp T, Bernards R, Agami R, Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 2002;296:550–553

PII: S0188-4409(09)00041-1

doi: 10.1016/j.arcmed.2009.03.001

Archives of Medical Research
Volume 40, Issue 4 , Pages 235-240 , May 2009

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