Archives of Medical Research
Volume 40, Issue 6 , Pages 428-434 , August 2009

HPV-related Carcinogenesis: Basic Concepts, Viral Types and Variants

  • Marcela Lizano

      Affiliations

    • Unidad de Cáncer, Investigación Biomédica en División de Investigación Basica, Instituto Nacional de Cancerología, SSA, Mexico, D.F., Mexico
    • Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico, D.F., Mexico
    • Corresponding Author InformationAddress reprint requests to: Marcela Lizano, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Av. San Fernando No. 22, Col. Sección XVI, CP 14080, Tlalpan, Mexico, D.F., Mexico; Phone: (+52) (55) 5628 0400 ext. 133
    • ,
  • Jaime Berumen

      Affiliations

    • Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico, D.F., Mexico
    • Departamento de Virología y Genómica, Hospital General de México, SSA, Mexico, D.F., Mexico
    • ,
  • Alejandro García-Carrancá

      Affiliations

    • Unidad de Cáncer, Investigación Biomédica en División de Investigación Basica, Instituto Nacional de Cancerología, SSA, Mexico, D.F., Mexico
    • Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico, D.F., Mexico

Received 27 May 2006 ,Accepted 28 May 2006.

References 

  1. Doorbar J. The papillomavirus life cycle. J Clin Virol. 2005;32S1:S7–S15
  2. Schwarz E, Freese UK, Gissmann L, et al. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature. 1985;314:111–114
  3. Schneider-Maunoury S, Croissant O, Orth G. Integration of human papillomavirus type 16 DNA sequences: a possible early event in the progression of genital tumors. J Virol. 1987;61:3295–3298
  4. Cullen AP, Reid R, Campion M, et al. Analysis of the physical state of different human-papillomavirus DNAs in intra-epithelial and invasive cervical neoplasm. J Virol. 1991;65:606–612
  5. Berumen J, Unger ER, Casas L, et al. Amplification of human papillomavirus types 16 and 18 in invasive cervical cancer. Hum Pathol. 1995;26:676–681
  6. Münger K, Phelps WC, Bubb V, et al. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J Virol. 1989;63:4417–4421
  7. Hawley-Nelson P, Vousden KH, Hubbert NL, et al. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J. 1989;8:3905–3910
  8. Alfandari J, Shnitman Magal S, Jackman A, et al. HPV16 E6 oncoprotein inhibits apoptosis induced during serum-calcium differentiation of foreskin human keratinocytes. Virology. 1999;257:383–396
  9. Cheng S, Schmidt-Grimminger DC, Murant T, et al. Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes. Genes Dev. 1995;9:2335–2349
  10. Woodworth CD, Cheng S, Simpson S, et al. Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection. Oncogene. 1992;7:619–626
  11. Rapp L, Chen JJ. The papillomavirus E6 proteins. Biochim Biophys Acta. 1998;1378:F1–F19
  12. Scheffner M, Werness BA, Huibregtse JM, et al. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 1990;63:1129–1136
  13. Dyson N, Guida P, Munger K, et al. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol. 1992;66:6893–6902
  14. Beaudenon S, Huibregtse J. HPV E6, E6AP and cervical cancer. BMC Biochemistry. 2008;9(Suppl 1):S4
  15. Foster SA, Galloway DA. Human papillomavirus type 16 E7 alleviates a proliferation block in early passage human mammary epithelial cells. Oncogene. 1996;12:1773–1779
  16. zur Hausen H. Papillomaviruses: to vaccination and beyond. Biochemistry (Moscow). 2008;73:498–503
  17. Steenbergen R, de Wilde J, Wilting S, et al. HPV-mediated transformation of the anogenital tract. J Clin Virol. 2005;32(Suppl 1):S25–S33
  18. Antinore MJ, Birrer MJ, Patel D, et al. The human papillomavirus type 16 E7 gene product interacts with and trans-activates the API family of transcription factors. EMBO J. 1996;15:1950–1960
  19. Klingelhutz AJ, Foster SA, McDougall JK. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature. 1996;380:79–81
  20. Torrisi A, Del Mistro A, Onnis GL, et al. Colposcopy, cytology and HPV testing in HIV-positive and HIV-negative women. Eur J Gynecol Oncol. 2000;21:168–172
  21. De Villiers EM, Fauqet C, Broker TR, et al. Classification of papillomaviruses. Virology. 2004;324:17–27
  22. Bernard HU. The clinical importance of nomenclature, evolution, and taxonomy of human papillomaviruses. J Clin Virol. 2005;32S:S1–S6
  23. Calleja-Macias IE, Kalantari M, Allan B, et al. Papillomavirus subtypes are natural and old taxa: phylogeny of human papillomavirus types 44 and 55 and 68a and -b. J Virol. 2005;79:6565–6569
  24. Ong CK, Chan SY, Campo MS, et al. Evolution of human papillomavirus 18: an ancient phylogenetic root in Africa and intratype diversity reflect coevolution with human ethnic groups. J Virol. 1993;67:6424–6431
  25. Yamada T, Manos MM, Peto J, et al. Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. J Virol. 1997;71:2463–2472
  26. Gissmann L, zur Hausen H. Partial characterization of viral DNA from human genital warts (condyloma acuminata). Int J Cancer. 1989;25:695–609
  27. De Villiers EM, Gissmann L, zur Hausen H. Molecular cloning of viral DNA from human genital warts. J Virol. 1981;40:932–935
  28. Gissmann L, Diehl V, Schultz-Coulon HJ, et al. Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma. J Virol. 1982;44:393–400
  29. Durst M, Gissmann L, Ikenberg H, et al. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA. 1983;80:3812–3815
  30. Boshart M, Gissmann L, Ikenberg H, et al. A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J. 1984;3:1151–1157
  31. Lorincz AT, Lancaster WD, Temple GF. Cloning and characterization of the DNA of a new human papillomavirus from women with dysplasia of the uterine cervix. J Virol. 1986;58:225–229
  32. Beaudendon S, Kremsdorf F, Croissant O, et al. A novel type of human papillomavirus associated with genital neoplasias. Nature. 1986;321:246–249
  33. Naghashfar ZS, Roseshein NB, Lorincz AT, et al. Characterization of human papillomavirus type 45, a new type 18-related virus of the genital tract. J Virol. 1987;68:3073–3079
  34. Takami Y, Kondoh G, Saito J, et al. Cloning and characterization of human papillomavirus type 52 from cervical carcinoma in Indonesia. Int J Cancer. 1991;48:516–522
  35. Matsukura T, Sugase M. Molecular cloning of a novel human papillomavirus (type 58) from an invasive cervical carcinoma. Virology. 1990;177:833–836
  36. Muñoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518–527
  37. de Sanjose S, Diaz M, Castellsague X, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007;7:453–459
  38. Gage JR, Meyers C, Wettstein FO. The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties. J Virol. 1990;64:723–730
  39. Ferenczy A, Franco E. Persistent human papillomavirus infection and cervical neoplasia. Lancet Oncol. 2002;3:11–16
  40. Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev. 2003;16:1–17
  41. Araujo Souza PS, Maciag PC, Ribeiro KB, et al. Interaction between polymorphisms of the human leukocyte antigen and HPV-16 variants on the risk of invasive cervical cancer. BMC Cancer. 2008;8:246
  42. Ishikawa H, Mitsuhashi N, Sakurai H, et al. The effects of p53 status and human papillomavirus infection on the clinical outcome of patients with stage IIIB cervical carcinoma treated with radiation therapy alone. Cancer. 2001;91:80–89
  43. Sousa H, Santos AM, Pinto D, et al. Is the p53 codon 72 polymorphism a key biomarker for cervical cancer development? A meta-analysis review within European populations. Int J Mol Med. 2007;20:731–741
  44. Goodman MT, McDuffie K, Hernandez B, et al. Association of methylenetetrahydrofolate reductase polymorphism C677T and dietary folate with the risk of cervical dysplasia. Cancer Epidemiol Biomarkers Prev. 2001;10:1275–1280
  45. Bernard HU, Callejas-Macias IE, Dunn T. Genome variation of human papillomavirus types: phylogenetic and medical implications. Int J Cancer. 2006;118:1071–1076
  46. Ho I, Chan SY, Burk RD, et al. The genetic drift of human papillomavirus type 16 is a means of reconstructing prehistoric viral spread and movement of ancient populations. J Virol. 1993;67:6413–6424
  47. Chen Z, DeSalle R, Schiffman M, et al. Evolutionary dynamics of variant genomes of human papillomavirus types 18, 45, and 97. J Virol. 2009;83:1443–1445
  48. Calleja-Macias IE, Kalantari M, Huh J, et al. Genomic diversity of human papillomavirus-16, 18, 31, and 35 isolates in a Mexican population and relationship to European, African, and Native American variants. Virology. 2004;319:315–323
  49. Londesborough P, Ho L, Terry G, et al. Human papillomavirus genotype as a predictor of persistence and development of high-grade lesions in women with minor cervical abnormalities. Int J Cancer. 1996;69:364–368
  50. Xi LF, Demers GW, Koutsky LA, et al. Analysis of human papillomavirus type 16 variants indicates establishment of persistent infection. J Infect Dis. 1995;172:747–755
  51. Xi LF, Koutsky LA, Galloway DA, et al. Genomic variation of human papillomavirus type 16 and risk for high grade cervical intraepithelial neoplasia. J Natl Cancer Inst. 1997;89:796–802
  52. Berumen J, Ordonez RM, Lazcano E, et al. Asian-American variants of human papillomavirus 16 and risk for cervical cancer. J Natl Can Inst. 2001;93:1325–1330
  53. Hildesheim A, Wang SS. Host and viral genetics and risk of cervical cancer: a review. Virus Res. 2002;89:229–240
  54. Lizano M, Berumen J, Guido MC, et al. Association between human papillomavirus type 18 variants and histopathology of cervical cancer. J Natl Cancer Inst. 1997;89:1227–1231
  55. Lizano M, De la Cruz-Hernández E, Carrillo-García A, et al. Distribution of HPV16 and 18 intratypic variants in normal cytology, intraepithelial lesions, and cervical cancer in a Mexican population. Gynecol Oncol. 2006;102:230–235
  56. De Boer MA, Peters LA, Aziz MF, et al. Human papillomavirus type 18 variants: histopathology and E6/E7 polymorphisms in three countries. Int J Cancer. 2005;114:422–425
  57. Burk RD, Terai M, Gravitt PE, et al. Distribution of human papillomavirus types 16 and 18 variants in squamous cell carcinomas and adenocarcinomas of the cervix. Cancer Res. 2003;63:7215–7220
  58. Stöppler MC, Ching K, Stöppler H, et al. Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation. J Virol. 1996;70:6987–6993
  59. Chakrabarti O, Veeraraghavalu K, Tergaonkar V, et al. Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic ras. J Virol. 2004;5934–5945
  60. Contreras-Paredes A, De la Cruz-Hernández E, Martínez-Ramírez I, et al. E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway. Virology. 2009;383:78–85
  61. De la Cruz-Hernández E, García-Carrancá A, Mohar-Betancourt A, et al. Differential splicing of E6 within human papillomavirus type 18 variants and functional consequences. J Gen Virol. 2005;86:2459–2468
  62. Veress G, Szarka K, Dong XP, et al. Functional significance of sequence variation in the E2 gene and the long control region of human papillomavirus type 16. J Gen Virol. 1999;80(Pt 4):1035–1043
  63. Kämmer C, Warthorst U, Torrez-Martinez N, et al. Sequence analysis of the long control region of human papillomavirus type 16 variants and functional consequences for P97 promoter activity. J Gen Virol. 2000;81:1975–1981
  64. Ndisang D, Faulkes DJ, Gascoyne D, et al. Differential regulation of different human papilloma virus variants by POU family transcription factor Brn-3a. Oncogene. 2006;25:51–60
  65. Hubert WG. Variant upstream regulatory region sequences differentially regulate human papillomavirus type 16 DNA replication throughout the viral life cycle. J Virol. 2005;79:5914–5922
  66. Sichero L, Franco EL, Villa LL. Different P105 promoter activities among natural variants of human papillomavirus type 18. J Infect Dis. 2005;191:739–742
  67. López-Saavedra A, González-Maya L, Ponce-de-León S, et al. Functional implication of sequence variation in the long control region and E2 gene among human papillomavirus type 18 variants. Arch Virol. 2009;154:745–754
  68. Ordóñez RM, Espinosa AM, Sánchez-González DJ, et al. Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7-oncogenes transcription. J Gen Virol. 2004;85:1433–1444

PII: S0188-4409(09)00092-7

doi: 10.1016/j.arcmed.2009.06.001

Archives of Medical Research
Volume 40, Issue 6 , Pages 428-434 , August 2009

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