Archives of Medical Research
Volume 40, Issue 7 , Pages 561-564 , October 2009

Does Defective Apoptosis Play A Role in Cystic Fibrosis Lung Disease?

Received 10 November 2008 ,Accepted 22 June 2009.

References 

  1. Maiuri L, Raia V, De Marco G, et al. DNA fragmentation is a feature of cystic fibrosis epithelial cells: a disease with inappropriate apoptosis?. FEBS Lett. 1997;408:225–231
  2. Durieu I, Amsellem C, Paulin C, et al. Fas and Fas ligand expression in cystic fibrosis airway epithelium. Thorax. 1999;54:1093–1098
  3. Amsellem C, Durieu I, Chambe MT, et al. In vitro expression of Fas and CD40 and induction of apoptosis in human cystic fibrosis airway epithelial cells. Respir Med. 2002;96:244–249
  4. Mitola S, Sorbello V, Ponte E, et al. Tumor necrosis factor-alpha in airway secretions from cystic fibrosis patients upregulate endothelial adhesion molecules and induce airway epithelial cell apoptosis: implications for cystic fibrosis lung disease. Int J Immunopathol Pharmacol. 2008;21:851–865
  5. Rottner M, Freyssinet JM, Martínez MC. Mechanisms of the noxious inflammatory cycle in cystic fibrosis. Respir Res. 2009;10:23
  6. Gottlieb RA, Dosan JH. Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: possible relevance to cystic fibrosis. Proc Natl Acad Sci USA. 1996;93:3587–3591
  7. Woo GH, Bak EJ, Nakayama H, et al. Hydroxyurea (HU)-induced apoptosis in the mouse fetal lung. Exp Mol Pathol. 2005;79:59–67
  8. Behnia M, Robertson KA, Martin WJ. Role of apoptosis in host defence and pathogenesis of disease. Chest. 2000;117:1771–1777
  9. Kahl BC, Goulian M, Wamel WV, et al. Staphylococcus aureus RN6390 replicates and induces apoptosis in a pulmonary epithelial cell line. Infect Immun. 2000;68:5385–5392
  10. Rajan S, Cacalono G, Bryan R, et al. Pseudomonas aeruginosa induction of apoptosis in respiratory epithelial cells. Am J Respir Cell Mol Biol. 2000;23:304–312
  11. Cannon CL, Kowalski MP, Stopak KS, et al. Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol. 2003;29:188–197
  12. Engelhardt JF, Zepeda M, Cohn J, et al. Expression of the cystic fibrosis gene in adult human lung. J Clin Invest. 1994;93:737–749
  13. Yokohori N, Aoshiba K, Nagai A. Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest. 2004;125:626–632
  14. Tateyama H, Tada T, Hattori H, et al. Effects of prefixation and fixation times on apoptosis detection by in situ end-labeling of fragmented DNA. Arch Pathol Lab Med. 1998;122:252–255

PII: S0188-4409(09)00131-3

doi: 10.1016/j.arcmed.2009.07.005

Archives of Medical Research
Volume 40, Issue 7 , Pages 561-564 , October 2009

Article Tools

* Image Usage & Resolution