Archives of Medical Research
Volume 41, Issue 1 , Pages 26-32 , January 2010

Multiple Correlations Between Cord Blood Leptin Concentration and Indices of Neonatal Growth

  • Ali Awsat Mellati

      Affiliations

    • Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
    • ,
  • Seideh Mazloomzadeh

      Affiliations

    • Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
    • ,
  • Afagh Anjomshoaa

      Affiliations

    • Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
    • ,
  • Mohsen Alipour

      Affiliations

    • Physiology Department, Zanjan Medical School, Zanjan, Iran
    • ,
  • Fatemeh Karimi

      Affiliations

    • Pediatric Department, Movsavi Hospital, Zanjan, Iran
    • ,
  • Sahar Mazloomi

      Affiliations

    • Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
    • ,
  • Seyed Ali Naghi Kazemi

      Affiliations

    • Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
    • Corresponding Author InformationAddress reprint requests to: Seyed Ali Naghi Kazemi, MD, Associate Professor, Zanjan Medical School, Pediatric Department, Mousavi Hospital, Shahrak Karmandan, Zanjan, Islamic Republic of Iran; Phone: 00982414130000; Fax: 00984249553

Received 12 June 2009 ,Accepted 30 October 2009.

References 

  1. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425–432
  2. Halass JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543–546
  3. Freedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395:763–770
  4. Farooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002;110:1093–1103
  5. Mise H, Yura S, Itoh H, et al. The relationship between maternal plasma leptin levels and fetal growth restriction. Endocr J. 2007;54:945–951
  6. Hauguel-de Mouzon S, Lepercq J, Catalano P. The known and unknown of leptin in pregnancy. Am J Obstet Gynecol. 2006;194:1537–1546
  7. Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of weight change on plasma leptin concentrations and energy expenditure. J Clin Endocrinol Metab. 1997;82:3647–3654
  8. Alexe DM, Syndou G, Petridou ET. Determinants of early life leptin levels and later life degenerative outcomes. Clin Med Res. 2006;4:326–335
  9. Christou H, Serdy S, Mantzoros CS. Leptin in relation to growth and developmental processes in the fetus. Semin Reprod Med. 2002;20:123–130
  10. Collinson A, Moore S, O'Connell M, et al. Developmental changes in leptin as a measure of energy status in human infants in a natural ecologic setting. Am J Clin Nutr. 2005;81:481–494
  11. Linnemann K, Malek A, Sager R, et al. Leptin production and release in the dually in vitro perfused human placenta. J Clin Endocrinol Metab. 2000;85:4298–4301
  12. Catov JM, Patrick TE, Powers RW, et al. Maternal leptin across pregnancy in women with small for gestational infants. Am J Obstet Gynecol. 2007;196:558.e1–558.e8
  13. Lepercq J, Guerre-Millo M, Andue J, et al. Leptin: a potential marker of placental insufficiency. Obstet Gynecol. 2000;55:151–155
  14. Laivuori H, Gallaher MJ, Collura L, et al. Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. Mol Hum Reprod. 2006;12:551–556
  15. Matsuda J, Yokota I, Iida M, et al. Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab. 1997;82:1642–1644
  16. Vatten LJ, Nilsen ST, Odegard RA, et al. Insulin like growth factor I and leptin in umbilical cord plasma and infant birth size at term. Pediatrics. 2002;109:1131–1135
  17. Watanobe H, Habu S. Manipulation of neonatal gonadal steroid milieu and leptin secretion in later life in male and female rats. Regul Pept. 2003;110:219–224
  18. Tsai PJ, Yu CH, Hsu SP, et al. Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birth weight and neonatal adiposity. Clin Endocrinol (Oxf). 2004;61:88–93
  19. Christou H, Connors JM, Ziotopoulou M, et al. Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth. J Clin Endocrinol Metab. 2001;86:935–938
  20. Papageorgiou I, Messinis IE, Milingos S, et al. Relation between leptin and cortisol values in umbilical vessels at normal vaginal delivery. J Matern Fetal Neonatal Med. 2004;16:303–307
  21. Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998;392:398–401
  22. Faroogi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med. 1999;341:879–884
  23. Schubring C, Kiess W, Englaro P, et al. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J Clin Endocrinol Metab. 1997;82:1480–1483
  24. Schubring C, Siebler T, Kratzsch J, et al. Leptin serum concentrations in healthy neonates within the first week of life: relation to insulin and growth hormone levels, skinfold thickness, body mass index and weight. Clin Endocrinol (Oxf). 1999;51:199–204
  25. Persson B, Westgren M, Celsi G, et al. Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers. Horm Metab Res. 1999;31:467–471
  26. Grisaru-Granovskv S, Samueloff A, Elstein D. The role of leptin in fetal growth: a short review. Eur J Obstet Gynecol Reprod Biol. 2008;136:146–150
  27. Ben X, Qin Y, Wu S, et al. Placental leptin correlates with intrauterine fetal growth and development. Clin Med J (Engl). 2001;114:636–639
  28. Martin-Gronert MS, Qzanne SE. Programming of appetite and type 2 diabetes. Early Hum Dev. 2005;81:981–988
  29. Fridwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  30. Zhang N, Wu XY, Wu XP, et al. Relationship between age-related serum concentrations of TGF-β1 and TGF-β2 and those of osteoprotegerin and leptin in native Chinese women. Clin Chim Acta. 2009;403:63–69
  31. Chow VT, Phoon MC. Measurement of serum leptin concentrations in university undergraduates by competitive ELISA reveals correlations with body mass index and sex. Adv Physiol Educ. 2005;27:70–77
  32. Söderberg S, Ahren B, Eliasson M, et al. The association between leptin and proinsulin is lost with central obesity. J Intern Med. 2002;252:140–148
  33. Kyriakakou M, Malamitsi-Puchner A, Militsi H, et al. Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers. Eur J Endocrinol. 2008;158:343–348
  34. Harigaya A, Nagashima K, Nako y, et al. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab. 1997;82:3281–3284
  35. Sarandakou A, Protonotariou E, Rizos D, et al. Serum leptin concentrations during the perinatal period. Am J Perinatol. 2000;17:325–328
  36. Kratzsch J, Schubring C, Stitzel B, et al. Inverse changes in the serum levels of the soluble leptin receptor and leptin in neonates: Relations to anthropometric data. J Clin Endocrinol Metab. 2005;90:2212–2217
  37. Park MJ, Namgung R, Kim JN, et al. Serum leptin, IGF-1 and insulin in preterm infants receiving parenteral nutrition during the first week of life. J Pediatr Endocrinol Metab. 2001;14:429–433
  38. Ng PC, Lam CW, Lee CH, et al. Leptin and metabolic hormones in preterm newborns. Arch Dis Child Fetal Neonatal Ed. 2000;83:198–202
  39. Walker CD, Salzmann C, Long H, et al. Direct effects of leptin on the neonatal adrenal and potential consequences for brain glucocorticoid feedback. Endocr Res. 2004;30:827–844
  40. Yeung LP, Wong AC, Wang X, et al. Different relationship between anthropometric markers and umbilical cord plasma leptin in Asian and Caucasian neonates. Pediatr Res. 2003;53:1019–1024
  41. Petridou E, Mantzoros CS, Belechri M, et al. Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf). 2005;62:366–371
  42. Vohr BR, McGarvey ST. Growth patterns of large-for-gestational-age and appropriate-for-gestational-age infants of gestational diabetes mothers and control mothers at 1 year. Diabetes Care. 1997;20:1066–1072
  43. Mantzoros CS, Rifas-Shiman SL, Williams CJ, et al. Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study. Pediatrics. 2009;123:682–689
  44. Freedman DS, Dietz WH, Srinivasan SR, et al. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics. 1999;103:1175–1182
  45. Collinson A, Moore S, O'Connell M, et al. Developmental changes in leptin as a measure of energy status in human infants in a natural ecologic setting. Am J Clin Nutr. 2005;81:488–494
  46. Field AE, Coakley EH, Must A, et al. Impact of overweight on the risk of developing common chronic diseases during a 10 year period. Arch Int Med. 2001;161:1581–1586
  47. Willett WC, Dietz WH, Colditz GA. Guidelines for healthy weight. N Engl J Med. 1999;341:427–434
  48. Yajnik CS, Lubree HG, Rege SS, et al. Adiposity and hyperinsulinemia in Indians are present at birth. J Clin Enclocrinol Metab. 2002;87:5575–5580
  49. Chowdhury B, Lantz H, Jostrom L S. Computed tomography-determined body composition in relation to cardiovascular risk factors in Indian and matched Swedish males. Metabolism. 1996;45:634–644
  50. Banerji MA, Faridi N, Atluri R, et al. Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J Clin Endocrinol Metab. 1999;84:137–144
  51. Deurenberg-Yap M, Schmidt G, van Staveren WA, et al. The paradox of low body mass index and high body fat percentage among Chinese, Malays and Indians in Singapore. Int J Obes Relat Metab Disord. 2000;24:1011–1017
  52. Martinez-Cordero C, Amador-Licona N, Guizar-Mendoza JM, et al. Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small for gestational age infants. Arch Med Res. 2006;37:490–494
  53. Ong KKL, Ahmed ML, Sherriff A, et al. Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. J Clin Endocrinol Metab. 1999;84:1145–1148
  54. Hytinantti T, Koistinen HA, Koivisto VA, et al. Changes in leptin concentration during the early postnatal period: adjustment to extrauterine life?. Pediatr Res. 1999;45:197–201
  55. Kayemba-Kay's S, Geary MP, Pringle J, et al. Gender, smoking during pregnancy and gestational age influence cord leptin concentrations in newborn infants. Eur J Endocrinol. 2008;159:217–224
  56. Roemmich JN, Rogol AD. Role of leptin during child hood growth and development. Endocrinol Metab Clin North Am. 1999;28:749–764
  57. Ertl T, Funke S, Sarakany I, et al. Postnatal change in leptin levels in full-term and preterm neonates: their relationship to intrauterine growth, gender and testosterone. Biol Neonate. 1999;75:167–176

PII: S0188-4409(09)00214-8

doi: 10.1016/j.arcmed.2009.12.001

Archives of Medical Research
Volume 41, Issue 1 , Pages 26-32 , January 2010

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