Archives of Medical Research
Volume 41, Issue 1 , Pages 50-58 , January 2010

RANTES Gene Polymorphisms and Asthma Risk: A Meta-Analysis

  • Yong-Gang Zhang

      Affiliations

    • Department of Respiratory Medicine, West China Medical School of Sichuan University, Chengdu, Sichuan, China
    • These authors contributed equally to this work.
  • ,
  • Jin Huang

      Affiliations

    • Chinese Evidence-Based Medicine/Cochrane Center, Chengdu, Sichuan, China
    • These authors contributed equally to this work.
  • ,
  • Jie Zhang

      Affiliations

    • Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, China
  • ,
  • Xiao-Bo Li

      Affiliations

    • Department of Respiratory Medicine, West China Medical School of Sichuan University, Chengdu, Sichuan, China
  • ,
  • Chao He

      Affiliations

    • Department of Laboratory Medicine, West China Medical School of Sichuan University, Chengdu, Sichuan, China
  • ,
  • Yu-Ling Xiao

      Affiliations

    • Department of Laboratory Medicine, West China Medical School of Sichuan University, Chengdu, Sichuan, China
  • ,
  • Can Tian

      Affiliations

    • Department of Respiratory Medicine, West China Medical School of Sichuan University, Chengdu, Sichuan, China
  • ,
  • Hua Wan

      Affiliations

    • Department of Health Statistics, West China Medical School of Sichuan University, Chengdu, Sichuan, China
  • ,
  • Yu-Liang Zhao

      Affiliations

    • West China Medical School of Sichuan University, Chengdu, Sichuan, China
  • ,
  • Yangzom-Ghising Tsewang

      Affiliations

    • Department of Respiratory Medicine, West China Medical School of Sichuan University, Chengdu, Sichuan, China
  • ,
  • Hong Fan

      Affiliations

    • Department of Respiratory Medicine, West China Medical School of Sichuan University, Chengdu, Sichuan, China
    • Department of Laboratory Medicine, West China Medical School of Sichuan University, Chengdu, Sichuan, China
    • Corresponding Author InformationAddress reprint requests to: Hong Fan, MD, Department of Respiratory Medicine, West China Hospital of Sichuan University, GuoXue Xiang 37, Chengdu, Sichuan, 610041 China; Phone: 86-28-85423520; FAX: 86-28-85423520

Received 27 September 2009 ,Accepted 14 December 2009.

References 

  1. Richter M, Cantin AM, Beaulieu C, et al. Zinc chelators inhibit eotaxin, RANTES, and MCP-1 production in stimulated human airway epithelium and fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2003;285:L719–L729
  2. Rojas-Ramos E, Avalos AF, Perez-Fernandez L, et al. Role of the chemokines RANTES, monocyte chemotactic proteins-3 and-4, and eotaxins-1 and-2 in childhood asthma. Eur Respir J. 2003;22:310–316
  3. Penido C, Castro-Faria-Neto HC, Vieira-de-Abreu A, et al. LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and eotaxin. Am J Resp Cell Mol. 2001;25:707–716
  4. Chung KF, Barnes PJ. Cytokines in asthma. Thorax. 1999;54:825–857
  5. Berkman N, Krishnan VL, Gilbey T, et al. Expression of RANTES mRNA and protein in airways of patients with mild asthma. Am J Respir Crit Care Med. 1996;154:1804–1811
  6. Powell N, Humbert M, Durham SR, et al. Increased expression of mRNA encoding RANTES and MCP-3 in the bronchial mucosa in atopic asthma. Eur Respir J. 1996;9:2454–2460
  7. Zietkowski Z, Tomasiak MM, Skiepko R, et al. RANTES in exhaled breath condensate of stable and unstable asthma patients. Respir Med. 2008;102:1198–1202
  8. Lachheb J, Chelbi H, Hamzaoui K, et al. Association between RANTES polymorphisms and asthma severity among Tunisian children. Hum Immunol. 2007;68:675–680
  9. Fryer AA, Spiteri MA, Bianco A, et al. The −403 G–>A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun. 2000;1:509–514
  10. Muro M, Marin L, Torio A, et al. CCL5/RANTES chemokine gene promoter polymorphisms are not associated with atopic and nonatopic asthma in a Spanish population. Int J Immunogenet. 2008;35:19–23
  11. Thakkinstian A, McEvoy M, Minelli C, et al. Systematic review and meta-analysis of the association between β2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol. 2005;162:201–211
  12. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–1101
  13. Egger M, Davey SG, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–634
  14. Al-Abdulhadi SA, Helms PJ, Main M, et al. Preferential transmission and association of the −403 G –> A promoter RANTES polymorphism with atopic asthma. Genes Immun. 2005;6:24–30
  15. Hizawa N, Yamaguchi E, Konno S, et al. A functional polymorphism in the RANTES gene promoter is associated with the development of late-onset asthma. Am J Respir Crit Care Med. 2002;166:686–690
  16. Liu M, Li HL, Huang YK, et al. The SNPs of chemokine RANTES promoter in children with asthma (Chinese). Zhong Guo You Sheng Yu Yi Chuan Za Zhi. 2005;13:20–24
  17. Moissidis I, Chinoy B, Yanamandra K, et al. Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans. Genet Med. 2005;7:406–410
  18. Sohn MH, Kim SH, Kim KW, et al. RANTES gene promoter polymorphisms are associated with bronchial hyperresponsiveness in Korean children with asthma. Lung. 2008;186:37–43
  19. Szalai C, Kozma GT, Nagy A, et al. Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity. J Allergy Clin Immunol. 2001;108:375–381
  20. Tolgyesi G, Keszei M, Ungvari I, et al. Involvement of TNFα −308A promoter polymorphism in the development of asthma in children infected with Chlamydophila pneumoniae. Pediatr Res. 2006;60:543–548
  21. Wang LJ, Li YR, Chen JH, et al. Polymorphism of regulated upon activation, normal T cell expressed and secreted promoter region −28 position in Chinese allergic asthmatic children (Chinese). Zhonghua Jie He He Hu Xi Za Zhi. 2004;27:394–397
  22. Yao TC, Kuo ML, See LC, et al. The RANTES promoter polymorphism: a genetic risk factor for near-fatal asthma in Chinese children. J Allergy Clin Immunol. 2003;111:1285–1292
  23. Tanaka K, Roberts MH, Yamamoto N, et al. Upregulating promoter polymorphisms of RANTES relate to atopic dermatitis. Int J Immunogenet. 2006;33:423–428
  24. Qiu LX, Li RT, Zhang JB, et al. The E-cadherin (CDH1)–160 C/A polymorphism and prostate cancer risk: a meta-analysis. Eur J Hum Genet. 2009;17:244–249
  25. Kato Y, Pawankar R, Kimura Y, et al. Increased expression of RANTES, CCR3 and CCR5 in the lesional skin of patients with atopic eczema. Int Arch Allergy Immunol. 2006;139:245–257
  26. Bai BX, Tanaka K, Tazawa T, et al. Association between RANTES promoter polymorphism −401A and enhanced RANTES production in atopic dermatitis patients. J Dermatol Sci. 2005;39:189–191
  27. Yao TC, Tsai YC, Huang JL. Association of RANTES promoter polymorphism with juvenile rheumatoid arthritis. Arthritis Rheum. 2009;60:1173–1178
  28. Mlynarski WM, Placha GP, Wolkow PP, et al. Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5)—A sex-specific effect. Diabetes. 2005;54:3331–3335
  29. Herder C, Illig T, Baumert J, et al. RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Eur J Endocrinol. 2008;158:R1–R5
  30. Saenz-Lopez P, Carretero R, Cozar JM, et al. Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer. BMC Cancer. 2008;8:382

PII: S0188-4409(10)00003-2

doi: 10.1016/j.arcmed.2010.01.002

Archives of Medical Research
Volume 41, Issue 1 , Pages 50-58 , January 2010