Archives of Medical Research
Volume 41, Issue 2 , Pages 142-146 , February 2010

TNF Polymorphisms in Patients with Behçet Disease: A Meta-analysis

  • Zahi Touma

      Affiliations

    • Department of Internal Medicine, Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    • ,
  • Chantal Farra

      Affiliations

    • Departments of Pathology and Laboratory Medicine, American University of Beirut, Beirut, Lebanon
    • ,
  • Ayad Hamdan

      Affiliations

    • Department of Internal Medicine, Division of Hematology-Oncology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    • ,
  • Wael Shamseddeen

      Affiliations

    • Chicago Medical School at Rosalind Franklin University, Division of Internal Medicine, Green Bay Road, North Chicago, Illinois
    • ,
  • Imad Uthman

      Affiliations

    • Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
    • ,
  • Hala Hourani

      Affiliations

    • Chronic Care Center, Genetic Lab, Hazmieh, Lebanon
    • ,
  • Thurayya Arayssi

      Affiliations

    • Weill Cornell Medical College-Qatar, Education City, Doha Qatar
    • Corresponding Author InformationAddress reprint requests to: Thurayya Arayssi M.D., Weill Cornell Medical College, Qatar, Education City, Doha Qatar; Phone: +974-492-8340: FAX: +974-492-8377:

Received 22 August 2009 ,Accepted 17 December 2009.

References 

  1. Arayssi T, Hamdan A. New insights into the pathogenesis and therapy of Behcet's disease. Curr Opinion Pharmacol. 2004;4:183–188
  2. Akman A, Sallakci N, Coskun M, et al. TNF-alpha gene 1031 T/C polymorphism in Turkish patients with Behcet's disease. Br J Dermatol. 2006;155:350–356
  3. Lee EB, Kim JY, Lee YJ, et al. TNF and TNF receptor polymorphisms in Korean Behcet's disease patients. Hum Immunol. 2003;64:614–620
  4. Gul A, Hajeer AH, Worthington J, et al. Linkage mapping of a novel susceptibility locus for Behcet's disease to chromosome 6p22–23. Arthritis Rheum. 2001;44:2693–2696
  5. Arayssi T, Hamra R, Homeidan F, et al. The efficacy of a single dose of infliximab in the treatment of Behcet's disease uveitis. Clin Exp Rheumatol. 2005;23:427
  6. Sfikakis PP, Markomichelakis N, Alpsoy E, et al. Anti-TNF therapy in the management of Behcet's disease–review and basis for recommendations. Rheumatology (Oxford). 2007;46:736–741
  7. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560
  8. Arayssi TK, Hamdan AR, Touma Z, et al. TNF polymorphisms in Lebanese patients with Behcet's disease. Clin Exp Rheumatol. 2008;26(suppl):130–131
  9. Verity DH, Wallace GR, Vaughan RW, et al. HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behcet's disease. Tissue Antigens. 1999;54:264–272
  10. Chang HK, Jang WC, Park SB, et al. The novel -G646A polymorphism of the TNF alpha promoter is associated with the HLA-B51 allele in Korean patients with Behcet's disease. Scand J Rheumatol. 2007;36:216–221
  11. Alayli G, Aydin F, Coban AY, et al. T helper 1 type cytokines polymorphisms: association with susceptibility to Behcet's disease. Clin Rheumatol. 2007;26:1299–1305
  12. Kamoun M, Chelbi H, Houman MH, et al. Tumor necrosis factor gene polymorphisms in Tunisian patients with Behcet's disease. Hum Immunol. 2007;68:201–205
  13. Park K, Kim N, Nam J, et al. Association of TNFA promoter region haplotype in Behcet's Disease. J Korean Med Sci. 2006;21:596–601
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  15. Duymaz-Tozkir J, Gul A, Uyar FA, et al. Tumour necrosis factor-alpha gene promoter region -308 and −376 G>A polymorphisms in Behcet's disease. Clin Exp Rheumatol. 2003;21(suppl):15–18
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  17. Storz K, Loffler J, Koch S, et al. IL-6 receptor, IL-8 receptor and TNF-alpha238 (G/A) polymorphisms are not associated with Behcet's disease in patients of German or Turkish origin. Clin Exp Rheumatol. 2008;26(suppl):103–106
  18. Akman A, Sallakci N, Kacaroglu H, et al. Relationship between periodontal findings and the TNF-alpha gene 1031T/C polymorphism in Turkish patients with Behcet's disease. J Eur Acad of Dermatol Venereol. 2008;22:950–957
  19. Khanna D, Wu H, Park G, et al. Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort. Arthritis Rheum. 2006;54:1105–1116
  20. Negoro K, Kinouchi Y, Hiwatashi N, et al. Crohn's disease is associated with novel polymorphisms in the 5′-flanking region of the tumor necrosis factor gene. Gastroenterology. 1999;117:1062–1068
  21. Kamizono S, Hiromatsu Y, Seki N, et al. A polymorphism of the 5′ flanking region of tumour necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese. Clin Endocrinol (Oxf). 2000;52:759–764
  22. Hajeer AH, Hutchinson IV. TNF-alpha gene polymorphism: clinical and biological implications. Microsc Res Tech. 2000;50:216–228
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  24. Kuo NW, Lympany PA, Menezo V, et al. TNF-857T, a genetic risk marker for acute anterior uveitis. Invest Ophthalmol Vis Sci. 2005;46:1565–1571
  25. Kang CP, Lee KW, Yoo DH, et al. The influence of a polymorphism at position −857 of the tumour necrosis factor alpha gene on clinical response to etanercept therapy in rheumatoid arthritis. Rheumatology (Oxford). 2005;44:547–552

PII: S0188-4409(10)00009-3

doi: 10.1016/j.arcmed.2010.02.002

Archives of Medical Research
Volume 41, Issue 2 , Pages 142-146 , February 2010

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