Archives of Medical Research
Volume 41, Issue 2 , Pages 75-82 , February 2010

Low-abundant Adiponectin Receptors in Visceral Adipose Tissue of Humans and Rats Are Further Reduced in Diabetic Animals

  • Sabrina Bauer

      Affiliations

    • Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany
  • ,
  • Johanna Weigert

      Affiliations

    • Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany
  • ,
  • Markus Neumeier

      Affiliations

    • Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany
  • ,
  • Josef Wanninger

      Affiliations

    • Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany
  • ,
  • Andreas Schäffler

      Affiliations

    • Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany
  • ,
  • Andreas Luchner

      Affiliations

    • Department of Internal Medicine II, Regensburg University Hospital, D-93042 Regensburg, Germany
  • ,
  • Andreas A. Schnitzbauer

      Affiliations

    • Department of Surgery, Regensburg University Hospital, D-93042 Regensburg, Germany
  • ,
  • Charalampos Aslanidis

      Affiliations

    • Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, D-93042 Regensburg, Germany
  • ,
  • Christa Buechler

      Affiliations

    • Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany
    • Corresponding Author InformationAddress reprint requests to: Christa Buechler, PhD, Department of Internal Medicine I, Regensburg University Hospital, D-93042 Regensburg, Germany; Phone: +49-941-944-7147; FAX: +49-941-944-7019.

Received 30 October 2009 ,Accepted 12 January 2010.

References 

  1. Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116:1784–1792
  2. Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762–769
  3. Fu Y, Luo N, Klein RL, et al. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J Lipid Res. 2005;46:1369–1379
  4. Otabe S, Yuan X, Fukutani T, et al. Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet. Am J Physiol Endocrinol Metab. 2007;293:E210–E218
  5. Bauche IB, El Mkadem SA, Pottier AM, et al. Overexpression of adiponectin targeted to adipose tissue in transgenic mice: impaired adipocyte differentiation. Endocrinology. 2007;148:1539–1549
  6. Ajuwon KM, Spurlock ME. Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1220–R1225
  7. Dietze-Schroeder D, Sell H, Uhlig M, et al. Autocrine action of adiponectin on human fat cells prevents the release of insulin resistance-inducing factors. Diabetes. 2005;54:2003–2211
  8. Rasmussen MS, Lihn AS, Pedersen SB, et al. Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots. Obesity (Silver Spring). 2006;14:28–35
  9. Fasshauer M, Klein J, Kralisch S, et al. Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes. FEBS Lett. 2004;558:27–32
  10. Ajuwon KM, Banz W, Winters TA. Stimulation with peptidoglycan induces interleukin 6 and TLR2 expression and a concomitant downregulation of expression of adiponectin receptors 1 and 2 in 3T3-L1 adipocytes. J Inflamm (Lond). 2009;6:8
  11. Guilherme A, Virbasius JV, Puri V, et al. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008;9:367–377
  12. Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008;29:2959–2971
  13. Nannipieri M, Bonotti A, Anselmino M, et al. Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic state. Int J Obes (Lond). 2007;31:1843–1848
  14. Li W, Tonelli J, Kishore P, et al. Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle. Am J Physiol Endocrinol Metab. 2007;292:E1301–E1307
  15. Metais C, Forcheron F, Abdallah P, et al. Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin. Metabolism. 2008;57:946–953
  16. Kim MJ, Maachi M, Debard C, et al. Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss. Eur J Endocrinol. 2006;155:161–165
  17. Nannipieri M, Cecchetti F, Anselmino M, et al. Pattern of expression of adiponectin receptors in human liver and its relation to nonalcoholic steatohepatitis. Obes Surg. 2009;19:467–474
  18. Tan GD, Debard C, Funahashi T, et al. Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. Diabetologia. 2005;48:1585–1589
  19. Rodriguez A, Catalan V, Becerril S, et al. Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats. Life Sci. 2008;83:540–549
  20. Mullen KL, Pritchard J, Ritchie I, et al. Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats. Am J Physiol Regul Integr Comp Physiol. 2009;296:R243–R251
  21. Weigert J, Neumeier M, Wanninger J, Wurm , et al. Reduced response to adiponectin and lower abundance of adiponectin receptor proteins in type 2 diabetic monocytes. FEBS Lett. 2008;582:1777–1782
  22. Neumeier M, Weigert J, Schaffler A, et al. Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. Biochem Biophys Res Commun. 2005;334:924–929
  23. Weigert J, Neumeier M, Bauer S, et al. Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release. FEBS Lett. 2008;582:2965–2972
  24. Schaffler A, Ehling A, Neumann E, et al. Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter. Biochim Biophys Acta. 2004;1678:150–156
  25. Fredersdorf S, Weil J, Ulucan C, et al. Vasopeptidase inhibition attenuates proteinuria and podocyte injury in Zucker diabetic fatty rats. Naunyn Schmiedebergs Arch Pharmacol. 2007;375:95–103
  26. Neumeier M, Hellerbrand C, Gabele E, et al. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. World J Gastroenterol. 2006;12:5490–5494
  27. Banga A, Unal R, Tripathi P, et al. Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids. Am J Physiol Endocrinol Metab. 2009;296:E480–E489
  28. Spiegelman BM, Frank M, Green H. Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem. 1983;258:10083–11009
  29. Schaeffler A, Gross P, Buettner R, et al. Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity. Immunology. 2008;126:233–245
  30. Combs TP, Wagner JA, Berger J, et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology. 2002;143:998–1007
  31. Perrini S, Laviola L, Cignarelli A, Melchiorre , et al. Fat depot-related differences in gene expression, adiponectin secretion, and insulin action and signalling in human adipocytes differentiated in vitro from precursor stromal cells. Diabetologia. 2008;51:155–164
  32. Ranganathan G, Li C, Kern PA. The translational regulation of lipoprotein lipase in diabetic rats involves the 3′-untranslated region of the lipoprotein lipase mRNA. J Biol Chem. 2000;275:40986–40991
  33. Samulin J, Berget I, Lien S, et al. Differential gene expression of fatty acid binding proteins during porcine adipogenesis. Comp Biochem Physiol B Biochem Mol Biol. 2008;151:147–152
  34. Zeigerer A, Rodeheffer MS, McGraw TE, et al. Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism. Exp Cell Res. 2008;314:2249–2256
  35. Barresi V, Grosso M, Giuffre G, et al. The expression of adiponectin receptors Adipo-R1 and Adipo-R2 is associated with an intestinal histotype and longer survival in gastric carcinoma. J Clin Pathol. 2009;62:705–709
  36. Pinthus JH, Kleinmann N, Tisdale B, et al. Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney. Eur Urol. 2008;54:866–873
  37. Yoneda K, Tomimoto A, Endo H, et al. Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. Oncol Rep. 2008;20:479–483
  38. Ishikawa M, Kitayama J, Kazama S, et al. Plasma adiponectin and gastric cancer. Clin Cancer Res. 2005;11:466–472
  39. Toyoda T, Kamei Y, Kato H, et al. Effect of peroxisome proliferator-activated receptor-alpha ligands in the interaction between adipocytes and macrophages in obese adipose tissue. Obesity (Silver Spring). 2008;16:1199–1207
  40. Yessoufou A, Ategbo JM, Attakpa E, et al. Peroxisome proliferator-activated receptor-alpha modulates insulin gene transcription factors and inflammation in adipose tissues in mice. Mol Cell Biochem. 2009;323:101–111
  41. Permana PA, Zhang W, Wabitsch M, et al. Pioglitazone reduces inflammatory responses of human adipocytes to factors secreted by monocytes/macrophages. Am J Physiol Endocrinol Metab. 2009;296:E1076–E1084
  42. Ohman MK, Wright AP, Wickenheiser KJ, et al. Visceral adipose tissue and atherosclerosis. Curr Vasc Pharmacol. 2009;7:169–179
  43. Walker CG, Sugden MC, Gibbons GF, et al. Peroxisome proliferator-activated receptor alpha deficiency modifies glucose handling by isolated mouse adipocytes. J Endocrinol. 2007;193:39–43
  44. Jeong S, Yoon M. Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice. Exp Mol Med. 2009;30:397–405

PII: S0188-4409(10)00024-X

doi: 10.1016/j.arcmed.2010.02.010

Archives of Medical Research
Volume 41, Issue 2 , Pages 75-82 , February 2010