Archives of Medical Research
Volume 41, Issue 3 , Pages 151-153 , April 2010

Comparison of Bioartificial Pancreas Performance in the Bone Marrow Cavity and Intramuscular Space

  • Kai-Chiang Yang

      Affiliations

    • Department of Organ Reconstruction, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    • Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan
    • ,
  • Chang-Chin Wu

      Affiliations

    • Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan
    • Department of Orthopedics, En Chu Kong Hospital, Taipei County, Taiwan
    • ,
  • Zhi Qi

      Affiliations

    • Department of Organ Reconstruction, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    • Department of Histology and Embryology, Nankai University School of Medicine, Nankai University, Tianjin, China
    • ,
  • Jung-Chih Chen

      Affiliations

    • Department of Organ Reconstruction, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    • National Science Council, Taipei, Taiwan
    • ,
  • Shoichiro Sumi

      Affiliations

    • Department of Organ Reconstruction, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    • ,
  • Feng-Huei Lin

      Affiliations

    • Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan
    • Division of Medical Engineering, National Health Research Institute, Miaoli County, Taiwan
    • Corresponding Author InformationAddress reprint requests to: Feng-Huei Lin, PhD, Prof., Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 1, Jen Ai Rd., Sec. 1, Taipei, 10051, Taiwan; Phone: (+886) 2-2312-3456 ex: 81456; FAX: (+886) 2-2394-0049

Received 13 November 2009 ,Accepted 8 February 2010.

References 

  1. Kobayashi N. Bioartificial pancreas for the treatment of diabetes. Cell Transpl. 2008;17:11–17
  2. Yang KC, Wu CC, Lin FH, et al. Chitosan/gelatin hydrogel as immunoisolative matrix for injectable bioartificial pancreas. Xenotransplantation. 2008;15:407–416
  3. de Groot M, Schuurs TA, Leuvenink HG, et al. Macrophage overgrowth affects neighboring nonovergrown encapsulated islets. J Surg Res. 2003;115:235–241
  4. de Groot M, Schuurs TA, van Schilfgaarde R. Causes of limited survival of microencapsulated pancreatic islet grafts. J Surg Res. 2004;121:141–150
  5. Salazar-Bañuelos A, Wright J, Sigalet D, Benítez-Bribiesca L. The bone marrow as a potential receptor site for pancreatic islet grafts. Arch Med Res. 2008;39:139–144
  6. Yang KC, Yang CY, Wu CC, et al. In vitro study of using calcium phosphate cement as immunoisolative device to enclose insulinoma/agarose microspheres as bioartificial pancreas. Biotechnol Bioeng. 2007;98:1288–1295
  7. Lin FH, Liao CJ, Chen KS, et al. Preparation of β-TCP/HAP biphasic ceramics with natural bone structure by heating bovine cancellous bone with the addition of (NH4)2HPO4. J Biomed Mater Res. 2000;51:157–163
  8. Yang KC, Wu CC, Sumi S, et al. Calcium phosphate cement chamber as an immunoisolative device for bioartificial pancreas: In vitro and preliminary in vivo study. Pancreas. 2010;
  9. Grant CS. Insulinoma. Best Pract Res Clin Gastroenterol. 2005;19:783–798
  10. de Groot M, Schuurs TA, Keizer PP, et al. Response of encapsulated rat pancreatic islets to hypoxia. Cell Transpl. 2003;12:867–875
  11. Witkowski P, Sondermeijer H, Hardy MA, et al. Islet grafting and imaging in a bioengineered intramuscular space. Transplantation. 2009;88:1065–1074
  12. Montgomery TM, Nelson RW, Feldman EC, et al. Basal and glucagon-stimulated plasma C-peptide concentrations in healthy dogs, dogs with diabetes mellitus, and dogs with hyperadrenocorticism. J Vet Intern Med. 1997;10:116–122
  13. Harrison JS, Rameshwar P, Chang V, et al. Oxygen saturation in the bone marrow of healthy volunteers. Blood. 2002;99:394
  14. Bavamian S, Klee P, Britan A, et al. Islet-cell-to-cell communication as basis for normal insulin secretion. Diabetes Obes Metab. 2007;S2:118–132
  15. Caton D, Calabrese A, Mas C, et al. Beta-cell crosstalk: a further dimension in the stimulus-secretion coupling of glucose-induced insulin release. Diabetes Metab. 2002;6(Pt 2):3S45–3S53
  16. Palmer JP, Fleming GA, Greenbaum CJ, et al. C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop. Diabetes. 2004;53:250–264

PII: S0188-4409(10)00027-5

doi: 10.1016/j.arcmed.2010.03.002

Archives of Medical Research
Volume 41, Issue 3 , Pages 151-153 , April 2010

Article Tools

* Image Usage & Resolution