Archives of Medical Research
Volume 41, Issue 2 , Pages 97-103 , February 2010

IL-8 −251 T > A Polymorphism Is Associated with Bladder Cancer Susceptibility and Outcome after BCG Immunotherapy in a Northern Indian Cohort

  • Dinesh Kumar Ahirwar
    • ,
  • Anil Mandhani
    • ,
  • Rama Devi Mittal

      Affiliations

    • Corresponding Author InformationAddress reprint requests to: Rama Devi Mittal, Additional Professor, Department of Urology, SGPGIMS, Raebareli Road, Lucknow-226014, India; Phone: 091-522-2668004-8, Ext. 2116; FAX: 091-522-2668017

Received 16 September 2009 ,Accepted 25 January 2010.

References 

  1. Sinha R, Anderson DE, McDonald SS, et al. Cancer risk and diet in India. J Postgrad Med. 2003;49:222–228
  2. Nadler RB, Catalona WJ, Hudson MA, et al. Durability of the tumor-free response for intravesical bacillus Calmette-Guerin therapy. J Urol. 1994;152:367–373
  3. Lamm DL. Long-term results of intravesical therapy for superficial bladder cancer. Urol Clin North Am. 1992;19:573–580
  4. Matsushima K, Baldwin ET, Mukaida N, et al. Interleukin-8 and MCAF: novel leukocyte recruitment and activating cytokines. Chem Immunol. 1992;51:236–265
  5. Wigmore SJ, Maingay JP, Fearon KC, et al. Endogenous production of IL-8 by human colorectal cancer cells and its regulation by cytokines. Int J Oncol. 2001;18:467–473
  6. Black PC, Dinney CP. Bladder cancer angiogenesis and metastasis–translation from murine model to clinical trial. Cancer Metastasis Rev. 2007;26:623–634
  7. Kumar A, Dubey D, Bansal P, et al. Urinary interleukin-8 predicts the response of standard and low dose intravesical bacillus Calmette-Guerin (modified Danish 1331 strain) for superficial bladder cancer. J Urol. 2002;168:2232–2235
  8. Mukaida N, Mahe Y, Matsushima K. Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J Biol Chem. 1990;265:21128–21133
  9. Barnes PJ, Karin M. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory Diseases. N Engl J Med. 1997;336:1066–1071
  10. Sumitomo M, Tachibana M, Ozu C, et al. Induction of apoptosis of cytokine-producing bladder cancer cells by adenovirus-mediated IκBα overexpression. Hum Gene Ther. 1999;10:37–47
  11. Wei YS, Lan Y, Tang RG, et al. Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal carcinoma. Clin Immunol. 2007;125:309–317
  12. Ohyauchi M, Imatani A, Yonechi M, et al. The polymorphism interleukin 8 −251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut. 2005;54:330–335
  13. Snoussi K, Mahfoudh W, Bouaouina N, et al. Genetic variation in IL-8 associated with increased risk and poor prognosis of breast carcinoma. Hum Immunol. 2006;67:3–21
  14. McCarron SL, Edwards S, Evans PR, et al. Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res. 2002;62:3369–3372
  15. Karban AS, Okazaki T, Panhuysen CI, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet. 2004;13:35–45
  16. Sobin LH, Fleming ID. TNM Classification of Malignant Tumours. Q12. 5th ed. New York: Wiley-Liss; 1997;
  17. Mittal RD, Singh R, Manchanda PK, et al. XRCC1 codon 399 mutant allele: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy. Cancer Biol Ther. 2008;7:645–650
  18. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215
  19. Hull J, Thomson A, Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax. 2000;55:1023–1027
  20. Renzoni E, Lympany P, Sestini P, et al. Distribution of novel polymorphisms of the interleukin-8 and CXC receptor 1 and 2 genes in systemic sclerosis and cryptogenic fibrosing alveolitis. Arthritis Rheum. 2000;43:1633–1640
  21. Zhou B, Rao L, Peng Y, et al. Functional polymorphism of the NFKB1 gene promoter is related to the risk of dilated cardiomyopathy. BMC Med Genet. 2009;10:47
  22. Excoffier L, Slatkin M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol. 1995;12:921–927
  23. Millan-Rodriguez F, Chéchile-Toniolo G, Salvador-Bayarri J, et al. Multivariate analysis of the prognostic factors of primary superficial bladder cancer. J Urol. 2000;163:73–78
  24. Lin WW, Karin MA. Cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007;117:1175–1183
  25. Rollins BJ. Inflammatory chemokines in cancer growth and progression. Eur J Cancer. 2006;42:760–767
  26. Vázquez-Lavista LG, Lima G, Gabilondo F, et al. Genetic association of monocyte chemoattractant protein 1 (MCP-1)-2518 polymorphism in Mexican patients with transitional cell carcinoma of the bladder. Urology. 2009;7:414–418
  27. Bohle A, Nowc C, Ulmer AJ, et al. Elevations of cytokines interleukin-1, interleukin-2 and tumor necrosis factor in the urine of patients after intravesical bacillus Calmette-Guerin immunotherapy. J Urol. 1990;144:59–64
  28. Bettex-Galland M, Studer UE, Walz A, et al. Neutrophil-activating peptide-1/interleukin-8 detection in human urine during acute bladder inflammation caused by transurethral resection of superficial cancer and bacillus Calmette-Guerin administration. Eur Urol. 1991;192:171–175
  29. de Boer EC, Somogyi L, de Ruiter GJ, et al. Role of interleukin-8 in onset of the immune response in intravesical BCG therapy for superficial bladder cancer. Urol Res. 1997;25:31–34
  30. Thalmann GN, Sermier A, Rentsch C, et al. Urinary interleukin-8 and 18 predict the response of superficial bladder cancer to intravesical therapy with bacillus Calmette-Guerin. J Urol. 2000;164:2129–2133
  31. Baeuerle PA. The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. Biochim Biophys Acta. 1991;1072:63–80
  32. Vairaktaris E, Yapijakis C, Serefoglou Z, et al. The interleukin-8 (−251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma. Eur J Surg Oncol. 2007;33:504–507
  33. Leibovici D, Grossman HB, Dinney CP, et al. Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival. J Clin Oncol. 2005;23:5746–5756

PII: S0188-4409(10)00030-5

doi: 10.1016/j.arcmed.2010.03.005

Archives of Medical Research
Volume 41, Issue 2 , Pages 97-103 , February 2010

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