Archives of Medical Research
Volume 41, Issue 4 , Pages 288-294 , May 2010

Anti-oxidant Effects of Resveratrol on Mice with DSS-induced Ulcerative Colitis

  • Jun Yao

      Affiliations

    • Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen, Guangdong Province, China
  • ,
  • Jian-Yao Wang

      Affiliations

    • Department of General Surgery, Shenzhen Municipal People's Hospital, Jinan University of Medical Sciences, Shenzhen, Guangdong Province, China
  • ,
  • Lei Liu

      Affiliations

    • Department of General Surgery, Shenzhen Municipal People's Hospital, Jinan University of Medical Sciences, Shenzhen, Guangdong Province, China
  • ,
  • Ying-Xue Li

      Affiliations

    • Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen, Guangdong Province, China
  • ,
  • An-Ying Xun

      Affiliations

    • Department of Gastroenterology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China
  • ,
  • Wei-Sen Zeng

      Affiliations

    • Department of Cell Biology, Southern Medical University, Guangzhou, Guangdong Province, China
  • ,
  • Chun-Hong Jia

      Affiliations

    • Department of Cell Biology, Southern Medical University, Guangzhou, Guangdong Province, China
  • ,
  • Xiao-Xia Wei

      Affiliations

    • Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen, Guangdong Province, China
  • ,
  • Ju-Ling Feng

      Affiliations

    • Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen, Guangdong Province, China
  • ,
  • Li Zhao

      Affiliations

    • Department of Cell Biology, Southern Medical University, Guangzhou, Guangdong Province, China
  • ,
  • Li-Sheng Wang

      Affiliations

    • Department of Gastroenterology, Jinan University of Medical Sciences, Shenzhen Municipal People's Hospital, Shenzhen, Guangdong Province, China
    • Corresponding Author InformationAddress reprint requests to: Li-Sheng Wang, Department of Gastroenterology, Shenzhen Municipal People's Hospital, Jinan University of Medical Sciences, 1017 East Gate Road, Shenzhen, 518020, Guangdong Province, China; Phone: 0086-755-25533018; FAX: 0086-755-25533497

Received 1 November 2009 ,Accepted 27 April 2010.

References 

  1. Araki Y, Andoh A, Fujiyama Y. The free radical scavenger edaravone suppresses experimental dextran sulphate sodiuminduced colitis in rats. Int J Mol Med. 2003;12:125–129
  2. Bitirem M, Karakilcik AZ, Zerin M, et al. Protective effects of selenium and vitamin E combination on experimental colitis in blood plasma and colon of rats. Biol Trace Elem Res. 2009;23:[Epub ahead of print]
  3. Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics and prebiotics. Gastroenterology. 2004;126:1620–1633
  4. De Hertogh G, Aerssens J, Geboes KP, et al. Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease. World J Gastroenterol. 2008;14:845–852
  5. Dincer Y, Erzin Y, Himmetoglu S, et al. Oxidative DNA damage and antioxidant activity in patientsn with inflammatory bowel disease. Dig Dis Sci. 2007;52:1636–1641
  6. Naito Y, Takagi T, Yoshikawa T. Neutrophil-dependent oxidative stress in ulcerative colitis. J Clin Biochem Nutr. 2007;41:18–26
  7. Yoshida N, Murase H, Kunieda T, et al. Inhibitory effect of a novel water-soluble vitamin E derivative on atherosclerosis in rabbits. Atherosclerosis. 2002;162:111–117
  8. Keshavarzian A, Morgan G, Sedghi S, et al. Role of reactive oxygen metabolites in experimental colitis. Gut. 1990;31:786–790
  9. Seril DN, Liao J, Yang GY, et al. Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models. Carcinogenesis. 2003;24:353–362
  10. Clark RA, Epperson TK, Valente AJ. Mechanisms of activation of NADPH oxidases. Jpn J Infect Dis. 2004;57:22–23
  11. Park DW, Baek K, Kim JR, et al. Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1. Exp Mol Med. 2009;31:171–179
  12. Nauseef WM. Biological roles for the NOX family NADPH oxidases. J Biol Chem. 2008;283:16961–16965
  13. Wendeburg L, de Oliveira AC, Bhatia HS, et al. Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. J Neuroinflammation. 2009;14:6–26
  14. Zhu LX, Jin ZY, Luo X. Study on the antioxidant activity of the resveratrol and piceid. Food Res Dev. 2007;28:22–25
  15. Singh UP, Singh NP, Singh B, et al. Resveratrol (trans-3,5,4'-trihydroxystilbene) induces SIRT1 and down-regulates NF-κB activation to abrogate DSS-induced colitis. J Pharmacol Exp Ther. 2009;11(332):829–839[Epub ahead of print]
  16. Sands BE. Therapy of inflammatory bowel disease. Gastroenterology. 2000;118:68–82
  17. Katz JA. Advances in the medical therapy of inflammatory bowel disease. Curr Opin Gastroenterol. 2002;18:435–440
  18. Aberra FN, Lichtenstein GR. Infliximab in ulcerative colitis. Gastroenterol Clin North Am. 2006;35:821–836
  19. Feagan BG, Reinisch W, Rutgeerts P. The effects of infliximab therapy on health-related quality of life in ulcerative colitis patients. Am J Gastroenterol. 2007;102:794–802
  20. Nishimoto N, Nakahara H, Yoshio-Hoshino N, et al. Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody. Arthritis Rheum. 2008;58:1197–1200
  21. Ardizzone S, Bianchi Porro G. Biologic therapy for inflammatory bowel disease. Drugs. 2005;65:2253–2286
  22. Reddy JG, Loftus EV. Safety of infliximab and other biologic agents in the inflammatory bowel diseases. Gastroenterol Clin North Am. 2006;35:837–855
  23. Murthy SN, Cooper HS, Shim H, et al. Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporine. Dig Dis Sci. 1993;38:1722–1734
  24. Cooper HS, Murthy SN, Shah RS, et al. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest. 1993;69:238–249
  25. Murthy S, Murthy NS, Coppola D, et al. The efficacy of BAYy 1015 in dextran sulfate model of mouse colitis. Inflamm Res. 1997;46:224–233
  26. Hirata I, Yasumoto S, Toshina K, et al. Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis. World J Gastroenterol. 2007;13:1666–1671
  27. Kerem Z, Bilkis I, Flaishman MA, et al. Antioxidant activity and inhibition of alpha-glucosidase by trans-resveratrol, piceid, and a novel trans-stilbene from the roots of Israeli Rumex bucephalophorus L. J Agric Food Chem. 2006;54:1243–1247
  28. Dal Sasso M, Culici M, Guffanti EE, et al. A combination of budesonide and the SH-metabolite I of erdosteine acts synergistically in reducing chemiluminescence during human neutrophil respiratory burst. Pharmacology. 2005;74:127–134
  29. Hajj Hussein IA, Tohme R, Barada K, et al. Inflammatory bowel disease in rats: bacterial and chemical interaction. World J Gastroenterol. 2008;14:4028–4039
  30. Camuesco D, Gálvez J, Nieto A, et al. Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis. J Nutr. 2005;135:687–694
  31. Papadakis KA, Targan SR. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med. 2000;51:289–298
  32. Rogler G, Andus T. Cytokines in inflammatory bowel disease. World J Surg. 1998;22:382–389
  33. Isaacs KL, Sartor RB, Haskill S. Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification. Gastroenterology. 1992;103:1587–1595
  34. Blam ME, Stein RB, Lichtenstein GR. Integrating anti-tumor necrosis factor therapy in inflammatory bowel disease current and future perspectives. Am J Gastroenterol. 2001;96:1977–1997
  35. Chen HJ, Wu SB, Chang CM. Biological and dietary antioxidants protect against DNA nitration induced by reaction of hypochlorous acid with nitrite. Arch Biochem Biophys. 2003;415:109–116
  36. Karakilçik AZ, Hayat A, Zerin M, et al. Effects of intraperitoneally injected selenium and vitamin E in rats anesthetized with halothane. J Trace Elem Med Biol. 2003;17:33–38
  37. Ademoglu E, Erbil Y, Tam B, et al. Do Vitamin E and selenium have beneficial effects on rinitrobenzenesulfonic acid-induced experimental colitis. Dig Dis Sci. 2004;49:102–108
  38. Kruidenier L, Kuiper I, Lamers CB, et al. Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants. J Pathol. 2003;201:28–36
  39. Bai Y, Mao QQ, Qin J, et al. Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci. 2010;101:488–493
  40. Choi HY, Chong SA, Nam MJ. Resveratrol induces apoptosis in human SK-HEP-1 hepatic cancer cells. Cancer Genomics Proteomics. 2009;6:263–268
  41. Rubiolo JA, Mithieux G, Vega FV. Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes. Eur J Pharmacol. 2008;591:66–72
  42. Shang J, Chen LL, Xiao FX, et al. Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase. Acta Pharmacol Sin. 2008;29:698–706

PII: S0188-4409(10)00103-7

doi: 10.1016/j.arcmed.2010.05.002

Archives of Medical Research
Volume 41, Issue 4 , Pages 288-294 , May 2010