Archives of Medical Research
Volume 41, Issue 4 , Pages 269-274 , May 2010

Increased Insulin Resistance and Serum Resistin in Korean Patients with Behçet's Disease

  • Seong-Kyu Kim

      Affiliations

    • Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
    • Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Korea
    • These authors equally contributed to this paper.
  • ,
  • Jung-Yoon Choe

      Affiliations

    • Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
    • Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Korea
    • These authors equally contributed to this paper.
  • ,
  • Sung-Hoon Park

      Affiliations

    • Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
    • Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, Korea
  • ,
  • Sung Won Lee

      Affiliations

    • Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea
  • ,
  • Geon Ho Lee

      Affiliations

    • Department of Family Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
  • ,
  • Won Tae Chung

      Affiliations

    • Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea
    • Corresponding Author InformationAddress reprint requests to: Won Tae Chung, MD, PhD, Department of Internal Medicine, Dong-A University College of Medicine, 3-1 Dongdaeshin-Dong, SeoGu, Busan 602-715, Korea; Phone: +82-51-2402954; FAX: +82-51-2452954

Received 3 December 2009 ,Accepted 28 May 2010.

References 

  1. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet. 2005;365:1415–1428
  2. Uysal KT, Wiesbrock SM, Marino MW, et al. Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature. 1997;389:610–614
  3. Bastard JP, Maachi M, Van Nhieu JT, et al. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab. 2002;87:2084–2089
  4. Chung CP, Oeser A, Solus JF, et al. Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis. Atherosclerosis. 2008;196:756–763
  5. La Montagna G, Cacciapuoti F, Buono R, et al. Insulin resistance is an independent risk factor for atherosclerosis in rheumatoid arthritis. Diab Vasc Dis Res. 2007;4:130–135
  6. El Magadmi M, Ahmad Y, Turkie W, et al. Hyperinsulinemia, insulin resistance, and circulating oxidized low density lipoprotein in women with systemic lupus erythematosus. J Rheumatol. 2006;33:50–56
  7. Vadacca M, Margiotta D, Rigon A, et al. Adipokines and systemic lupus erythematosus: relationship with metabolic syndrome and cardiovascular disease risk factors. J Rheumatol. 2009;36:295–297
  8. Malesci D, Niglio A, Mennillo GA, et al. High prevalence of metabolic syndrome in patients with ankylosing spondylitis. Clin Rheumatol. 2007;26:710–714
  9. Sakane T, Takeno M, Suzuki N, et al. Behcet's disease. N Engl J Med. 1999;341:1284–1291
  10. International Study Group for Behcet's disease . Criteria for diagnosis of Behcet's disease. Lancet. 1990;335:1078–1080
  11. Zouboulis CC, Katsantonis J, Ketteler R, et al. Adamantiades-Behçet's disease: interleukin-8 is increased in serum of patients with active oral and neurological manifestations and is secreted by small vessel endothelial cells. Arch Dermatol Res. 2000;292:279–284
  12. Evereklioglu C, Er H, Türköz Y, et al. Serum levels of TNF-α, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behçet's disease. Mediators Inflamm. 2002;11:87–93
  13. Oguz A, Dogan EG, Uzunlulu M, et al. Insulin resistance and adiponectin levels in Behçet's syndrome. Clin Exp Rheumatol. 2007;25(4 Suppl. 45):S118–S119
  14. Erdem H, Dinc A, Pay S, et al. Peripheral insulin resistance in patients with Behçet's disease. J Eur Acad Dermatol Venereol. 2006;20:391–395
  15. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425–432
  16. Lago F, Dieguez C, Gómez-Reino J, et al. The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev. 2007;18:313–325
  17. Statnick MA, Beavers LS, Conner LJ, et al. Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes. Int J Exp Diabetes Res. 2000;1:81–88
  18. Senolt L, Housa D, Vernerová Z, et al. Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis. 2007;66:458–463
  19. Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307–312
  20. Yalçindag FN, Yalçindag A, Batioglu F, et al. Evaluation of serum resistin levels in patients with ocular and non-ocular Behçet's disease. Can J Ophthalmol. 2008;43:473–475
  21. Evereklioglu C, Inalöz HS, Kirtak N, et al. Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity. Br J Dermatol. 2002;147:331–336
  22. International Study Group for Behçet's disease . Criteria for diagnosis of Behçet's disease. Lancet. 1990;335:1078–1080
  23. Gül A, Esin S, Dilsen N, et al. Immunohistology of skin pathergy reaction in Behçet's disease. Br J Dermatol. 1995;132:901–907
  24. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  25. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497
  26. World Health Organisation, Western Pacific Region, The Asia-Pacific Perspective. Redefining Obesity and its Treatment, WHO/IASO/IOTF, 2000.
  27. Festa A, D'Agostino R, Howard G, et al. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000;102:42–47
  28. Temelkova-Kurktschiev T, Siegert G, Bergmann S, et al. Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes. Metabolism. 2002;51:743–749
  29. Hotamisligil GS, Arner P, Caro JF, et al. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest. 1995;95:2409–2415
  30. Pickup JC, Mattock MB, Chusney GD, et al. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia. 1997;40:1286–1292
  31. Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86:1930–1935
  32. Gonzalez-Gay MA, Llorca J, Garcia-Unzueta MT, et al. High-grade inflammation, circulating adiponectin concentrations and cardiovascular risk factors in severe rheumatoid arthritis. Clin Exp Rheumatol. 2008;26:596–603

PII: S0188-4409(10)00134-7

doi: 10.1016/j.arcmed.2010.05.008

Archives of Medical Research
Volume 41, Issue 4 , Pages 269-274 , May 2010